The constituents of Michelia compressa var. Formosana and their bioactivities

Yu Yi Chan; Shin Hun Juang; Guan Jhong Huang; Yu Ren Liao; Yu Fon Chen; Chia Che Wu; Hui Ting Chang; Tian Shung Wu

doi:10.3390/ijms150610926

The constituents of Michelia compressa var. Formosana and their bioactivities

Yu Yi Chan, Shin Hun Juang, Guan Jhong Huang, Yu Ren Liao, Yu Fon Chen, Chia Che Wu, Hui Ting Chang, Tian Shung Wu

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13 Citations (Scopus)

Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 μg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC₅₀ values in the range of 15.7-3.68 μM.

Original language	English
Pages (from-to)	10926-10935
Number of pages	10
Journal	International journal of molecular sciences
Volume	15
Issue number	6
DOIs	https://doi.org/10.3390/ijms150610926
Publication status	Published - 2014 Jun 17

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms150610926

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title = "The constituents of Michelia compressa var. Formosana and their bioactivities",

abstract = "Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 μg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.",

author = "Chan, {Yu Yi} and Juang, {Shin Hun} and Huang, {Guan Jhong} and Liao, {Yu Ren} and Chen, {Yu Fon} and Wu, {Chia Che} and Chang, {Hui Ting} and Wu, {Tian Shung}",

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T1 - The constituents of Michelia compressa var. Formosana and their bioactivities

AU - Chan, Yu Yi

AU - Juang, Shin Hun

AU - Huang, Guan Jhong

AU - Liao, Yu Ren

AU - Chen, Yu Fon

AU - Wu, Chia Che

AU - Chang, Hui Ting

AU - Wu, Tian Shung

PY - 2014/6/17

Y1 - 2014/6/17

N2 - Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 μg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.

AB - Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 μg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.

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The constituents of Michelia compressa var. Formosana and their bioactivities

Abstract

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