The constituents of Michelia compressa var. Formosana and their bioactivities

Yu Yi Chan, Shin Hun Juang, Guan Jhong Huang, Yu Ren Liao, Yu Fon Chen, Chia Che Wu, Hui Ting Chang, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 μg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.

Original languageEnglish
Pages (from-to)10926-10935
Number of pages10
JournalInternational journal of molecular sciences
Volume15
Issue number6
DOIs
Publication statusPublished - 2014 Jun 17

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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