The constituents of the stems of cissus assamica and their bioactivities

Yu Yi Chan, Chiu Yuan Wang, Tsong Long Hwang, Shin Hun Juang, Hsin Yi Hung, Ping Chung Kuo, Po Jen Chen, Tian Shung Wu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Fifty-five compounds were isolated from the fresh stems of Cissus assamica, including 14 benzenoids, 11 triterpenes, nine steroids, five tocopherols, five chlorophylls, four flavonoids, two benzoquinones, two tannins, and three other compounds. Their structures were constructed by 1D and 2D nuclear magnetic resonance (NMR) and mass spectral data, and were also identified by a comparison of their spectral data with those reported in the literature. Among these isolates, 1,2-bis-(5-tocopheryl) ethane (51) was reported for the first time from natural sources. Some purified compounds were examined for their anti-inflammatory and anticancer bioactivities. The results indicated that betulinic acid (16) exhibited strong inhibition of superoxide anion generation with IC50 value of 0.2 ± 0.1 μM, while betulinic acid (16) and pheophytin-a (47) inhibited elastase release with IC50 value of 2.7 ± 0.3 and 5.3 ± 1.0 μM, respectively. In addition, betulinic acid (16) and epiglut-5(6)-en-ol (18) exhibited potential cytotoxicity to non-small-cell lung carcinoma (NCI-H226) and colon cancer (HCT-116) cell lines with IC50 values in the range of 1.6 to 9.1 μM.

Original languageEnglish
Article number23112799
JournalMolecules
Volume23
Issue number11
DOIs
Publication statusPublished - 2018 Oct 28

Fingerprint

Cissus
Bioactivity
stems
Inhibitory Concentration 50
acids
Benzoquinones
cancer
Cells
HCT116 Cells
tocopherol
Triterpenes
steroids
Ethane
Tocopherols
inorganic peroxides
Pancreatic Elastase
Tannins
quinones
chlorophylls
Chlorophyll

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Chan, Y. Y., Wang, C. Y., Hwang, T. L., Juang, S. H., Hung, H. Y., Kuo, P. C., ... Wu, T. S. (2018). The constituents of the stems of cissus assamica and their bioactivities. Molecules, 23(11), [23112799]. https://doi.org/10.3390/molecules23112799
Chan, Yu Yi ; Wang, Chiu Yuan ; Hwang, Tsong Long ; Juang, Shin Hun ; Hung, Hsin Yi ; Kuo, Ping Chung ; Chen, Po Jen ; Wu, Tian Shung. / The constituents of the stems of cissus assamica and their bioactivities. In: Molecules. 2018 ; Vol. 23, No. 11.
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Chan, YY, Wang, CY, Hwang, TL, Juang, SH, Hung, HY, Kuo, PC, Chen, PJ & Wu, TS 2018, 'The constituents of the stems of cissus assamica and their bioactivities', Molecules, vol. 23, no. 11, 23112799. https://doi.org/10.3390/molecules23112799

The constituents of the stems of cissus assamica and their bioactivities. / Chan, Yu Yi; Wang, Chiu Yuan; Hwang, Tsong Long; Juang, Shin Hun; Hung, Hsin Yi; Kuo, Ping Chung; Chen, Po Jen; Wu, Tian Shung.

In: Molecules, Vol. 23, No. 11, 23112799, 28.10.2018.

Research output: Contribution to journalArticle

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