The core antigen of hepatitis B virus as a carrier for immunogenic peptides

Kenneth Murray, Ai-Li Shiau

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multi-component vaccines.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalBiological Chemistry
Volume380
Issue number3
DOIs
Publication statusPublished - 1999 Jan 1

Fingerprint

Hepatitis B Core Antigens
Viruses
Hepatitis B virus
Nucleocapsid
Antigens
Peptides
T-Lymphocyte Epitopes
Epitopes
Vaccines
Escherichia coli

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

Cite this

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The core antigen of hepatitis B virus as a carrier for immunogenic peptides. / Murray, Kenneth; Shiau, Ai-Li.

In: Biological Chemistry, Vol. 380, No. 3, 01.01.1999, p. 277-283.

Research output: Contribution to journalReview article

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