The core antigen of hepatitis B virus as a carrier for immunogenic peptides

Kenneth Murray, Ai Li Shiau

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)


The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multi-component vaccines.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalBiological Chemistry
Issue number3
Publication statusPublished - 1999 Mar

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry


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