The correlation between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient in healthy volunteers

Jin Fu Guo, Yen Kuang Yang, Nan Tsing Chiu, Tzung Lieh Yeh, Po See Chen, I. Hui Lee, Ching Lin Chu

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background. Although a correlation between the central dopaminergic system and intelligence may exist, the results from imaging studies remain inconclusive. The aim of this study was to explore the relationship between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient (VIQ) using single photon emission computed tomography (SPECT). Method. Striatal D2/D3 receptor availability of 64 healthy subjects was determined with the [123]iodobenzamide ([123]IBZM) ligand. Intelligence quotients (IQs) of the subjects were measured by the Wechsler Adult Intelligence Scale - Revised (WAIS-R). Results. In addition to age, left striatal D2/D3 receptor availability correlated positively with VIQ. In females, left striatal D2/D3 receptor availability was the only variable that correlated significantly with the similarities subtest of VIQ. Conclusions. There is a relationship between left striatal D2/ D3 receptor availability and verbal intelligence, which varies, predominantly in males.

Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalPsychological Medicine
Volume36
Issue number4
DOIs
Publication statusPublished - 2006 Apr

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

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