The death domain superfamily in intracellular signaling of apoptosis and inflammation

Ho Park Hyun, Yu Chih Lo, Su Chang Lin, Liwei Wang, Kuk Yang Jin, Hao Wu

Research output: Chapter in Book/Report/Conference proceedingChapter

358 Citations (Scopus)


The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.

Original languageEnglish
Title of host publicationAnnual Review of Immunology
EditorsWilliam Paul
Number of pages26
Publication statusPublished - 2007

Publication series

NameAnnual Review of Immunology
ISSN (Print)0732-0582

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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