Abstract
Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.
| Original language | English |
|---|---|
| Title of host publication | Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016 |
| Publisher | TechConnect |
| Pages | 148-151 |
| Number of pages | 4 |
| Volume | 3 |
| ISBN (Electronic) | 9780997511727 |
| Publication status | Published - 2016 |
| Event | 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States Duration: 2016 May 22 → 2016 May 25 |
Other
| Other | 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference |
|---|---|
| Country | United States |
| City | Washington |
| Period | 16-05-22 → 16-05-25 |
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All Science Journal Classification (ASJC) codes
- Fluid Flow and Transfer Processes
- Biotechnology
- Surfaces, Coatings and Films
- Fuel Technology
Cite this
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The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. / Cheng, F. Y.; Tsai, C. H.; Shieh, Dar-Bin; Huang, Jehn-Shun.
Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3 TechConnect, 2016. p. 148-151.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy
AU - Cheng, F. Y.
AU - Tsai, C. H.
AU - Shieh, Dar-Bin
AU - Huang, Jehn-Shun
PY - 2016
Y1 - 2016
N2 - Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.
AB - Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=84988964025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84988964025&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84988964025
VL - 3
SP - 148
EP - 151
BT - Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016
PB - TechConnect
ER -