The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy

F. Y. Cheng, C. H. Tsai, Dar-Bin Shieh, Jehn-Shun Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.

Original languageEnglish
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2016
PublisherTechConnect
Pages148-151
Number of pages4
Volume3
ISBN (Electronic)9780997511727
Publication statusPublished - 2016
Event10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference - Washington, United States
Duration: 2016 May 222016 May 25

Other

Other10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference
CountryUnited States
CityWashington
Period16-05-2216-05-25

Fingerprint

Mouth Neoplasms
Alginate
Drug delivery
Drug Delivery Systems
Pharmaceutical Preparations
Nanoparticles
Pharmacokinetics
Oncology
Chemotherapy
Neoplasms
Iron oxides
Doxorubicin
Therapeutics
alginic acid
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Fluid Flow and Transfer Processes
  • Biotechnology
  • Surfaces, Coatings and Films
  • Fuel Technology

Cite this

Cheng, F. Y., Tsai, C. H., Shieh, D-B., & Huang, J-S. (2016). The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016 (Vol. 3, pp. 148-151). TechConnect.
Cheng, F. Y. ; Tsai, C. H. ; Shieh, Dar-Bin ; Huang, Jehn-Shun. / The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3 TechConnect, 2016. pp. 148-151
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Cheng, FY, Tsai, CH, Shieh, D-B & Huang, J-S 2016, The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. in Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. vol. 3, TechConnect, pp. 148-151, 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 19th Annual Nanotech Conference and Expo, and the 2016 National SBIR/STTR Conference, Washington, United States, 16-05-22.

The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. / Cheng, F. Y.; Tsai, C. H.; Shieh, Dar-Bin; Huang, Jehn-Shun.

Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3 TechConnect, 2016. p. 148-151.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Oral cancer has been denoted as the sixth most common cancer in the world. Chemotherapy is one of the major therapeutics for advanced oral cancer cases. Advances in drug delivery system draw a niche for cancer treatment due to improved local therapeutic concentration, side effect control and pharmacokinetic profile. A novel drug delivery system made of superparamagnetic iron oxide nanoparticles (SPIONs) covalently linked with alginate was developed for oral cancer therapy. The results suggest that Fe3O4@Ca-alginate nanoparticles could effectively release doxorubicin in a spatial-temporal controlled manner and even achieved higher release rate in cancer intracellular compartments. These data suggest that Fe3O4@Ca-alginate could be a potential candidate of advanced drug delivery systems for advanced cancer therapy.

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Cheng FY, Tsai CH, Shieh D-B, Huang J-S. The development of multifunctional nanocomplexs for drug delivery in oral cancer therapy. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2016. Vol. 3. TechConnect. 2016. p. 148-151