The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure

J. E. Looney, C. Ma, T. H. Leu, W. F. Flintoff, W. B. Troutman, J. L. Hamlin

Research output: Contribution to journalArticle

17 Citations (Scopus)
Original languageEnglish
Pages (from-to)5268-6279
Number of pages1012
JournalMolecular and Cellular Biology
Volume8
Issue number12
Publication statusPublished - 1988 Jan 1

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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