The distribution of interleukin-19 in healthy and neoplastic tissue

Chung Hsi Hsing, Hsing Hui Li, Yu-Hsiang Hsu, Chung-Liang Ho, Shih Sung Chuang, Kuo Mao Lan, Ming-Shi Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The influence of interleukin (IL)-19, a recently discovered cytokine in the IL-10 family, on tissue is still unclear. Our aim was to determine the distribution of IL-19 expression and to delineate the cell types that express IL-19 in healthy and neoplastic tissue, because this information will significantly facilitate the exploration of its pathophysiological functions. We used tissue microarray technology and an immunohistochemical survey with an anti-IL-19 monoclonal antibody to examine the expression of IL-19 in 28 healthy and 15 neoplastic tissues. IL-19 protein was positively stained in 15 healthy tissue types and three major cell types: epithelial cells, endothelial cells, and macrophages. We also found that several types of tumor cells were positively stained for IL-19, especially in squamous cell carcinoma (SCC) of the skin, tongue, esophagus, and lung. SCC of the oral cavity expressed IL-19 mRNA and its receptors. In two cell lines derived from SCC of oral cavity tumor tissue, IL-19 specifically activated an intracellular signal and induced proliferation of the cells, which indicated that IL-19 may act in an autocrine manner in SCC tumors. This study provides important references for further investigation of the biological functions and clinical implications of IL-19 in humans.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalCytokine
Volume44
Issue number2
DOIs
Publication statusPublished - 2008 Nov 1

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Interleukins
Tissue
Squamous Cell Carcinoma
Tumors
Mouth
Cells
Neoplasms
Macrophages
Endothelial cells
Microarrays
Tongue
Interleukin-10
Esophagus
Skin
Endothelial Cells
Epithelial Cells
Monoclonal Antibodies
Cell Proliferation
Cytokines
Technology

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Hsing, Chung Hsi ; Li, Hsing Hui ; Hsu, Yu-Hsiang ; Ho, Chung-Liang ; Chuang, Shih Sung ; Lan, Kuo Mao ; Chang, Ming-Shi. / The distribution of interleukin-19 in healthy and neoplastic tissue. In: Cytokine. 2008 ; Vol. 44, No. 2. pp. 221-228.
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The distribution of interleukin-19 in healthy and neoplastic tissue. / Hsing, Chung Hsi; Li, Hsing Hui; Hsu, Yu-Hsiang; Ho, Chung-Liang; Chuang, Shih Sung; Lan, Kuo Mao; Chang, Ming-Shi.

In: Cytokine, Vol. 44, No. 2, 01.11.2008, p. 221-228.

Research output: Contribution to journalArticle

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