TY - JOUR
T1 - The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat
AU - Chen, Yu Wen
AU - Chu, Chin Chen
AU - Chen, Yu Chung
AU - Wang, Jhi Joung
AU - Hung, Ching Hsia
N1 - Funding Information:
The authors gratefully acknowledge the financial support provided for this study by the Cheng Hsin General Hospital ( 99-35 ) and the China Medical University ( CMU96-099 ) of Taiwan.
PY - 2010/9
Y1 - 2010/9
N2 - The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED50) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (P<0.01 for each comparison). On an equipotent basis (ED25, ED50, and ED75), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (P<0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.
AB - The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED50) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (P<0.01 for each comparison). On an equipotent basis (ED25, ED50, and ED75), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (P<0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.
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U2 - 10.1016/j.neulet.2010.07.011
DO - 10.1016/j.neulet.2010.07.011
M3 - Article
C2 - 20633604
AN - SCOPUS:77955549353
SN - 0304-3940
VL - 482
SP - 76
EP - 80
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -