The effect of allergen immunotherapy on in vitro 1L-4 and IFN-γ production by peripheral mononuclear cells in house dust-sensitive Chinese patients with bronchial asthma

Chrong Reen Wang, Szu Tsai Liu, Ming Fei Liu, Gwong Loon Lee, Gong Ren Wang, Che Yen Chuang

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Abstract

The IFN-γ produced by Th1 cells and IL-4 produced by Th2 cells are two most important cytokines in the regulation of IgE production. House dust immunotherapy has been tried in the treatment of house dust-sensitive Chinese asthmatic patients with good results. We examined the influence of such treatment on in vitro IL-4 and IFN-γ production by peripheral blood mononuclear cells in house dust-sensitive asthmatic patients. Allergen immunotherapy in house-dust sensitive asthmatic patients can significantly decrease IL-4 production from peripheral mononuclear cells (p < 0.05). The production levels of IL-4 in patients without treatment had higher levels than those in patients with hyposensitization (P < 0.01). Such therapy also have some effect on promotion of IFN-γ production in asthmatic patients. In conclusion, immunotherapy with house dust may have the potential ability to shift the Th1/Th2 balance of immune response to allergens and to create a favorable cytokine microenvironment to suppress the allergic reaction in the asthmatic airway.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalAsian Pacific Journal of Allergy and Immunology
Volume17
Issue number4
Publication statusPublished - 1999 Dec 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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