The IFN-γ produced by Th1 cells and IL-4 produced by Th2 cells are two most important cytokines in the regulation of IgE production. House dust immunotherapy has been tried in the treatment of house dust-sensitive Chinese asthmatic patients with good results. We examined the influence of such treatment on in vitro IL-4 and IFN-γ production by peripheral blood mononuclear cells in house dust-sensitive asthmatic patients. Allergen immunotherapy in house-dust sensitive asthmatic patients can significantly decrease IL-4 production from peripheral mononuclear cells (p < 0.05). The production levels of IL-4 in patients without treatment had higher levels than those in patients with hyposensitization (P < 0.01). Such therapy also have some effect on promotion of IFN-γ production in asthmatic patients. In conclusion, immunotherapy with house dust may have the potential ability to shift the Th1/Th2 balance of immune response to allergens and to create a favorable cytokine microenvironment to suppress the allergic reaction in the asthmatic airway.
|Number of pages||6|
|Journal||Asian Pacific Journal of Allergy and Immunology|
|Publication status||Published - 1999 Dec|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy