The effect of dexamethasone on postoperative pain emesis after intrathecal neostigmine

Ping Heng Tan, Kang Liu, Chih Hsien Peng, Ling Cheng Yang, Chung Ren Lin, Cheng Yuan Lu

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41 Citations (Scopus)

Abstract

We evaluated the effect of a single dose of dexamethasone on the incidence and severity of postoperative nausea and vomiting (PONV) after intrathecal injection of tetracaine plus neostigmine. Sixty ASA physical status I patients scheduled for inguinal herniorrhaphy were studied with a randomized, double-blinded, placebo-controlled protocol. The dexamethasone group (Group D) received 10 mg of dexamethasone IV before performance of spinal anesthesia, whereas the placebo group (Group P) received saline. Spinal anesthesia was performed with intrathecal injection of 15 mg tetracaine plus neostigmine 100 μg in both groups. Pain, PONV, and other side effects were evaluated 24 h after surgery. The duration and severity of analgesia and the incidence of PONV were not significantly different between the two groups. Our results demonstrate that a single dose of dexamethasone (10 mg) did not potentiate the analgesic effect or reduce the incidence of PONV after intrathecal injection of tetracaine and neostigmine.

Original languageEnglish
Pages (from-to)228-232
Number of pages5
JournalAnesthesia and analgesia
Volume92
Issue number1
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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