The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing

K. C. Hung, C. W. Chen, V. C.H. Lin, H. C. Weng, Shao Wei Hsieh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 μg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Six hundred patients were randomly assigned to one of three groups to receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 μg (3 ml), or pre-emptive fentanyl 25 μg (0.5 ml) 1 min before administration of fentanyl 125 μg or 150 μg. The incidence of fentanyl-induced cough was significantly lower in both pre-emptive groups (7 (3.5%) for 125 μg fentanyl and 15 (7.5%) for 150 lg fentanyl) than in the saline group (37 (18.5%); p = 0.001). We conclude that pre-emptive use of fentanyl 25 μg, administered 1 min before bolus injection of fentanyl (125 or 150 μg), can effectively suppress fentanyl-induced cough.

Original languageEnglish
Pages (from-to)4-7
Number of pages4
JournalAnaesthesia
Volume65
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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