The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice

Dur Zong Hsu, Se Ping Chien, Ke Ting Chen, Ming Yie Liu

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study investigated the effect of sesamol (3,4-methylenedioxyphenol) on systemic oxidative stress and hepatic function in acutely iron-intoxicated mice. Sesamol reduced the levels of lipid peroxidation, hydroxyl radical, iron production and superoxide anion generation, and xanthine oxidase activity in iron-intoxicated mice. In addition, sesamol decreased the serum levels of aspartate aminotransferase and alanine aminotransferase, and ameliorated iron-intoxication-induced histological changes in the liver. In summary, sesamol might attenuate systemic oxidative stress by reducing xanthine oxidase and improving hepatic function in iron-intoxicated mice.

Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalShock
Volume28
Issue number5
DOIs
Publication statusPublished - 2007 Nov 1

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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