TY - JOUR
T1 - The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice
AU - Hsu, Dur Zong
AU - Chien, Se Ping
AU - Chen, Ke Ting
AU - Liu, Ming Yie
PY - 2007/11
Y1 - 2007/11
N2 - This study investigated the effect of sesamol (3,4-methylenedioxyphenol) on systemic oxidative stress and hepatic function in acutely iron-intoxicated mice. Sesamol reduced the levels of lipid peroxidation, hydroxyl radical, iron production and superoxide anion generation, and xanthine oxidase activity in iron-intoxicated mice. In addition, sesamol decreased the serum levels of aspartate aminotransferase and alanine aminotransferase, and ameliorated iron-intoxication-induced histological changes in the liver. In summary, sesamol might attenuate systemic oxidative stress by reducing xanthine oxidase and improving hepatic function in iron-intoxicated mice.
AB - This study investigated the effect of sesamol (3,4-methylenedioxyphenol) on systemic oxidative stress and hepatic function in acutely iron-intoxicated mice. Sesamol reduced the levels of lipid peroxidation, hydroxyl radical, iron production and superoxide anion generation, and xanthine oxidase activity in iron-intoxicated mice. In addition, sesamol decreased the serum levels of aspartate aminotransferase and alanine aminotransferase, and ameliorated iron-intoxication-induced histological changes in the liver. In summary, sesamol might attenuate systemic oxidative stress by reducing xanthine oxidase and improving hepatic function in iron-intoxicated mice.
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U2 - 10.1097/shk.0b013e31804d4474
DO - 10.1097/shk.0b013e31804d4474
M3 - Article
C2 - 17589387
AN - SCOPUS:37349079471
SN - 1073-2322
VL - 28
SP - 596
EP - 601
JO - Shock
JF - Shock
IS - 5
ER -