The Effectiveness of 23-valent Pneumococcal Polysaccharide Vaccine on Elderly Colorectal Cancer Long-Term Survivors: A population-based exact-matched cohort study

Moon Sing Lee, Shin Yi Chiou, Feng Chun Hsu, Hon Yi Lin, Chung Yi Li, Shih Kai Hung, Ben Hui Yu, Chin Chia Wu, Liang Cheng Chen, Chia Hui Chew, Wen Yen Chiou

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000–2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 (p =.391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.

Original languageEnglish
Article number2350093
JournalHuman Vaccines and Immunotherapeutics
Volume20
Issue number1
DOIs
Publication statusPublished - 2024

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Fingerprint

Dive into the research topics of 'The Effectiveness of 23-valent Pneumococcal Polysaccharide Vaccine on Elderly Colorectal Cancer Long-Term Survivors: A population-based exact-matched cohort study'. Together they form a unique fingerprint.

Cite this