Abstract
Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000–2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 (p =.391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.
Original language | English |
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Article number | 2350093 |
Journal | Human Vaccines and Immunotherapeutics |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2024 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Pharmacology