The effects of acupuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats

Hung Chien Wu, Jaung Geng Lin, Chun-Hsien Chu, Yung Hsien Chang, Chung Gwo Chang, Ching Liang Hsieh, Angela Hsin Chieh Tsai, Kwo Chang Ueng, Wei Wen Kuo, James A. Lin, Jer Yuh Liu, Chih Yang Huang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

If acupuncture is able to prevent hypertrophy of the heart, it could therefore prevent the heart from overloading and thus prevent heart failure or sudden death. We therefore studied the effects of acupuncture on blood pressure and cardiac muscle cells. Rats with spontaneous hypertension were divided into three acupuncture treatment groups and one non-treatment group. The treatment groups were classified as sham acupoint, Yanglingquan (GB. 34) and Quchi (L1. 11) groups. The measurements recorded included changes in tail pressure, femoral arterial pressure, left ventricular weight (LVW), whole heart weight (WHW), body weight (BW), LVW/BW and WHW/BW ratios and the size of the cardiac muscle cells. The results showed that femoral arterial pressure of subjects which were needled on the selected points for 3 days dropped. Acupuncture at these two acupoints seemed to improve the condition of hypertension in a short period of time. Significant changes in the femoral arterial pressure were observed in all subjects when they were treated for 6 days. In the two acupoint groups, the LVW/BW and the WHW/BW ratios did not change significantly. Cardiac muscle cells reduced in size in the Yanglingquan (GB. 34) treatment groups. This indicates that the Yanglingquan (GB. 34) points not only can lower blood pressure, but also prevent hypertrophy of cardiac muscle cells in spontaneous hypertensive rats (SHR). Therefore, acupuncture could be a good treatment modality for hypertension and hypertrophy of the heart.

Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalAcupuncture and Electro-Therapeutics Research
Volume29
Issue number1-2
DOIs
Publication statusPublished - 2004 Jan 1

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Acupuncture
Cardiac Myocytes
Blood Pressure
Weights and Measures
Acupuncture Points
Body Weight
Thigh
Arterial Pressure
Cardiomegaly
Hypertension
Acupuncture Therapy
Sudden Death
Hypertrophy
Tail
Therapeutics
Heart Failure
Pressure

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Complementary and alternative medicine
  • Anesthesiology and Pain Medicine

Cite this

Wu, Hung Chien ; Lin, Jaung Geng ; Chu, Chun-Hsien ; Chang, Yung Hsien ; Chang, Chung Gwo ; Hsieh, Ching Liang ; Tsai, Angela Hsin Chieh ; Ueng, Kwo Chang ; Kuo, Wei Wen ; Lin, James A. ; Liu, Jer Yuh ; Huang, Chih Yang. / The effects of acupuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats. In: Acupuncture and Electro-Therapeutics Research. 2004 ; Vol. 29, No. 1-2. pp. 83-95.
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abstract = "If acupuncture is able to prevent hypertrophy of the heart, it could therefore prevent the heart from overloading and thus prevent heart failure or sudden death. We therefore studied the effects of acupuncture on blood pressure and cardiac muscle cells. Rats with spontaneous hypertension were divided into three acupuncture treatment groups and one non-treatment group. The treatment groups were classified as sham acupoint, Yanglingquan (GB. 34) and Quchi (L1. 11) groups. The measurements recorded included changes in tail pressure, femoral arterial pressure, left ventricular weight (LVW), whole heart weight (WHW), body weight (BW), LVW/BW and WHW/BW ratios and the size of the cardiac muscle cells. The results showed that femoral arterial pressure of subjects which were needled on the selected points for 3 days dropped. Acupuncture at these two acupoints seemed to improve the condition of hypertension in a short period of time. Significant changes in the femoral arterial pressure were observed in all subjects when they were treated for 6 days. In the two acupoint groups, the LVW/BW and the WHW/BW ratios did not change significantly. Cardiac muscle cells reduced in size in the Yanglingquan (GB. 34) treatment groups. This indicates that the Yanglingquan (GB. 34) points not only can lower blood pressure, but also prevent hypertrophy of cardiac muscle cells in spontaneous hypertensive rats (SHR). Therefore, acupuncture could be a good treatment modality for hypertension and hypertrophy of the heart.",
author = "Wu, {Hung Chien} and Lin, {Jaung Geng} and Chun-Hsien Chu and Chang, {Yung Hsien} and Chang, {Chung Gwo} and Hsieh, {Ching Liang} and Tsai, {Angela Hsin Chieh} and Ueng, {Kwo Chang} and Kuo, {Wei Wen} and Lin, {James A.} and Liu, {Jer Yuh} and Huang, {Chih Yang}",
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Wu, HC, Lin, JG, Chu, C-H, Chang, YH, Chang, CG, Hsieh, CL, Tsai, AHC, Ueng, KC, Kuo, WW, Lin, JA, Liu, JY & Huang, CY 2004, 'The effects of acupuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats', Acupuncture and Electro-Therapeutics Research, vol. 29, no. 1-2, pp. 83-95. https://doi.org/10.3727/036012904815901515

The effects of acupuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats. / Wu, Hung Chien; Lin, Jaung Geng; Chu, Chun-Hsien; Chang, Yung Hsien; Chang, Chung Gwo; Hsieh, Ching Liang; Tsai, Angela Hsin Chieh; Ueng, Kwo Chang; Kuo, Wei Wen; Lin, James A.; Liu, Jer Yuh; Huang, Chih Yang.

In: Acupuncture and Electro-Therapeutics Research, Vol. 29, No. 1-2, 01.01.2004, p. 83-95.

Research output: Contribution to journalArticle

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T1 - The effects of acupuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats

AU - Wu, Hung Chien

AU - Lin, Jaung Geng

AU - Chu, Chun-Hsien

AU - Chang, Yung Hsien

AU - Chang, Chung Gwo

AU - Hsieh, Ching Liang

AU - Tsai, Angela Hsin Chieh

AU - Ueng, Kwo Chang

AU - Kuo, Wei Wen

AU - Lin, James A.

AU - Liu, Jer Yuh

AU - Huang, Chih Yang

PY - 2004/1/1

Y1 - 2004/1/1

N2 - If acupuncture is able to prevent hypertrophy of the heart, it could therefore prevent the heart from overloading and thus prevent heart failure or sudden death. We therefore studied the effects of acupuncture on blood pressure and cardiac muscle cells. Rats with spontaneous hypertension were divided into three acupuncture treatment groups and one non-treatment group. The treatment groups were classified as sham acupoint, Yanglingquan (GB. 34) and Quchi (L1. 11) groups. The measurements recorded included changes in tail pressure, femoral arterial pressure, left ventricular weight (LVW), whole heart weight (WHW), body weight (BW), LVW/BW and WHW/BW ratios and the size of the cardiac muscle cells. The results showed that femoral arterial pressure of subjects which were needled on the selected points for 3 days dropped. Acupuncture at these two acupoints seemed to improve the condition of hypertension in a short period of time. Significant changes in the femoral arterial pressure were observed in all subjects when they were treated for 6 days. In the two acupoint groups, the LVW/BW and the WHW/BW ratios did not change significantly. Cardiac muscle cells reduced in size in the Yanglingquan (GB. 34) treatment groups. This indicates that the Yanglingquan (GB. 34) points not only can lower blood pressure, but also prevent hypertrophy of cardiac muscle cells in spontaneous hypertensive rats (SHR). Therefore, acupuncture could be a good treatment modality for hypertension and hypertrophy of the heart.

AB - If acupuncture is able to prevent hypertrophy of the heart, it could therefore prevent the heart from overloading and thus prevent heart failure or sudden death. We therefore studied the effects of acupuncture on blood pressure and cardiac muscle cells. Rats with spontaneous hypertension were divided into three acupuncture treatment groups and one non-treatment group. The treatment groups were classified as sham acupoint, Yanglingquan (GB. 34) and Quchi (L1. 11) groups. The measurements recorded included changes in tail pressure, femoral arterial pressure, left ventricular weight (LVW), whole heart weight (WHW), body weight (BW), LVW/BW and WHW/BW ratios and the size of the cardiac muscle cells. The results showed that femoral arterial pressure of subjects which were needled on the selected points for 3 days dropped. Acupuncture at these two acupoints seemed to improve the condition of hypertension in a short period of time. Significant changes in the femoral arterial pressure were observed in all subjects when they were treated for 6 days. In the two acupoint groups, the LVW/BW and the WHW/BW ratios did not change significantly. Cardiac muscle cells reduced in size in the Yanglingquan (GB. 34) treatment groups. This indicates that the Yanglingquan (GB. 34) points not only can lower blood pressure, but also prevent hypertrophy of cardiac muscle cells in spontaneous hypertensive rats (SHR). Therefore, acupuncture could be a good treatment modality for hypertension and hypertrophy of the heart.

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