The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms

San Yu Wang, I. Mei Lin, Sheng-Yu Fan, Yu Che Tsai, Cheng Fang Yen, Yi Chun Yeh, Mei Feng Huang, Yu Lee, Nien Mu Chiu, Chi Fa Hung, Peng Wei Wang, Tai Ling Liu, Huang Chi Lin

Research output: Contribution to journalArticle

Abstract

Background: Alpha-asymmetry neurofeedback (ALAY) was applied to patients with major depressive disorder (MDD) based on the theory of frontal alpha asymmetry. Neurophysiological studies have found a higher high-beta activity of electroencephalography (EEG) at the posterior cortex among patients with comorbid MDD and anxiety symptoms. The present study examined the effects of ALAY and high-beta down-training (Beta) neurofeedback in symptoms of depression and anxiety and EEG parameters. Method: Eighty-seven patients with comorbid MDD and anxiety symptoms were allocated to the ALAY, Beta, or control groups. Both neurofeedback groups received ten-session neurofeedback. All participants completed the Beck Depression Inventory II (BDI-II), Beck Anxiety Inventory (BAI), and five minutes resting EEG recording at pre-test and post-test. EEG raw signals were transformed into an A1 score [log (F4 alpha) - log (F3 alpha)], P3 and P4 high-beta power. Results: BDI-II and BAI scores decreased at post-test in both ALAY and Beta groups, but no significant difference between the two groups. No significant interaction effect in A1 score at pre-test and post-test between the ALAY, Beta, and control groups. The P3 high-beta was significantly decreased in the Beta group, an increase in the control group, and no change in the ALAY group at post-test compared to the pre-test. Conclusions: Both neurofeedback groups decreased symptoms of depression and anxiety. The Beta group was more effective in decreasing high-beta power at the parietal cortex compared to other groups. This non-invasive psychological intervention can be used in the future for patients with comorbid MDD and anxiety symptoms.

Original languageEnglish
Pages (from-to)287-296
Number of pages10
JournalJournal of Affective Disorders
Volume257
DOIs
Publication statusPublished - 2019 Oct 1

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Neurofeedback
Major Depressive Disorder
Anxiety
Electroencephalography
Depression
Equipment and Supplies
Control Groups
Parietal Lobe

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Wang, San Yu ; Lin, I. Mei ; Fan, Sheng-Yu ; Tsai, Yu Che ; Yen, Cheng Fang ; Yeh, Yi Chun ; Huang, Mei Feng ; Lee, Yu ; Chiu, Nien Mu ; Hung, Chi Fa ; Wang, Peng Wei ; Liu, Tai Ling ; Lin, Huang Chi. / The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms. In: Journal of Affective Disorders. 2019 ; Vol. 257. pp. 287-296.
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title = "The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms",
abstract = "Background: Alpha-asymmetry neurofeedback (ALAY) was applied to patients with major depressive disorder (MDD) based on the theory of frontal alpha asymmetry. Neurophysiological studies have found a higher high-beta activity of electroencephalography (EEG) at the posterior cortex among patients with comorbid MDD and anxiety symptoms. The present study examined the effects of ALAY and high-beta down-training (Beta) neurofeedback in symptoms of depression and anxiety and EEG parameters. Method: Eighty-seven patients with comorbid MDD and anxiety symptoms were allocated to the ALAY, Beta, or control groups. Both neurofeedback groups received ten-session neurofeedback. All participants completed the Beck Depression Inventory II (BDI-II), Beck Anxiety Inventory (BAI), and five minutes resting EEG recording at pre-test and post-test. EEG raw signals were transformed into an A1 score [log (F4 alpha) - log (F3 alpha)], P3 and P4 high-beta power. Results: BDI-II and BAI scores decreased at post-test in both ALAY and Beta groups, but no significant difference between the two groups. No significant interaction effect in A1 score at pre-test and post-test between the ALAY, Beta, and control groups. The P3 high-beta was significantly decreased in the Beta group, an increase in the control group, and no change in the ALAY group at post-test compared to the pre-test. Conclusions: Both neurofeedback groups decreased symptoms of depression and anxiety. The Beta group was more effective in decreasing high-beta power at the parietal cortex compared to other groups. This non-invasive psychological intervention can be used in the future for patients with comorbid MDD and anxiety symptoms.",
author = "Wang, {San Yu} and Lin, {I. Mei} and Sheng-Yu Fan and Tsai, {Yu Che} and Yen, {Cheng Fang} and Yeh, {Yi Chun} and Huang, {Mei Feng} and Yu Lee and Chiu, {Nien Mu} and Hung, {Chi Fa} and Wang, {Peng Wei} and Liu, {Tai Ling} and Lin, {Huang Chi}",
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Wang, SY, Lin, IM, Fan, S-Y, Tsai, YC, Yen, CF, Yeh, YC, Huang, MF, Lee, Y, Chiu, NM, Hung, CF, Wang, PW, Liu, TL & Lin, HC 2019, 'The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms', Journal of Affective Disorders, vol. 257, pp. 287-296. https://doi.org/10.1016/j.jad.2019.07.026

The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms. / Wang, San Yu; Lin, I. Mei; Fan, Sheng-Yu; Tsai, Yu Che; Yen, Cheng Fang; Yeh, Yi Chun; Huang, Mei Feng; Lee, Yu; Chiu, Nien Mu; Hung, Chi Fa; Wang, Peng Wei; Liu, Tai Ling; Lin, Huang Chi.

In: Journal of Affective Disorders, Vol. 257, 01.10.2019, p. 287-296.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms

AU - Wang, San Yu

AU - Lin, I. Mei

AU - Fan, Sheng-Yu

AU - Tsai, Yu Che

AU - Yen, Cheng Fang

AU - Yeh, Yi Chun

AU - Huang, Mei Feng

AU - Lee, Yu

AU - Chiu, Nien Mu

AU - Hung, Chi Fa

AU - Wang, Peng Wei

AU - Liu, Tai Ling

AU - Lin, Huang Chi

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Alpha-asymmetry neurofeedback (ALAY) was applied to patients with major depressive disorder (MDD) based on the theory of frontal alpha asymmetry. Neurophysiological studies have found a higher high-beta activity of electroencephalography (EEG) at the posterior cortex among patients with comorbid MDD and anxiety symptoms. The present study examined the effects of ALAY and high-beta down-training (Beta) neurofeedback in symptoms of depression and anxiety and EEG parameters. Method: Eighty-seven patients with comorbid MDD and anxiety symptoms were allocated to the ALAY, Beta, or control groups. Both neurofeedback groups received ten-session neurofeedback. All participants completed the Beck Depression Inventory II (BDI-II), Beck Anxiety Inventory (BAI), and five minutes resting EEG recording at pre-test and post-test. EEG raw signals were transformed into an A1 score [log (F4 alpha) - log (F3 alpha)], P3 and P4 high-beta power. Results: BDI-II and BAI scores decreased at post-test in both ALAY and Beta groups, but no significant difference between the two groups. No significant interaction effect in A1 score at pre-test and post-test between the ALAY, Beta, and control groups. The P3 high-beta was significantly decreased in the Beta group, an increase in the control group, and no change in the ALAY group at post-test compared to the pre-test. Conclusions: Both neurofeedback groups decreased symptoms of depression and anxiety. The Beta group was more effective in decreasing high-beta power at the parietal cortex compared to other groups. This non-invasive psychological intervention can be used in the future for patients with comorbid MDD and anxiety symptoms.

AB - Background: Alpha-asymmetry neurofeedback (ALAY) was applied to patients with major depressive disorder (MDD) based on the theory of frontal alpha asymmetry. Neurophysiological studies have found a higher high-beta activity of electroencephalography (EEG) at the posterior cortex among patients with comorbid MDD and anxiety symptoms. The present study examined the effects of ALAY and high-beta down-training (Beta) neurofeedback in symptoms of depression and anxiety and EEG parameters. Method: Eighty-seven patients with comorbid MDD and anxiety symptoms were allocated to the ALAY, Beta, or control groups. Both neurofeedback groups received ten-session neurofeedback. All participants completed the Beck Depression Inventory II (BDI-II), Beck Anxiety Inventory (BAI), and five minutes resting EEG recording at pre-test and post-test. EEG raw signals were transformed into an A1 score [log (F4 alpha) - log (F3 alpha)], P3 and P4 high-beta power. Results: BDI-II and BAI scores decreased at post-test in both ALAY and Beta groups, but no significant difference between the two groups. No significant interaction effect in A1 score at pre-test and post-test between the ALAY, Beta, and control groups. The P3 high-beta was significantly decreased in the Beta group, an increase in the control group, and no change in the ALAY group at post-test compared to the pre-test. Conclusions: Both neurofeedback groups decreased symptoms of depression and anxiety. The Beta group was more effective in decreasing high-beta power at the parietal cortex compared to other groups. This non-invasive psychological intervention can be used in the future for patients with comorbid MDD and anxiety symptoms.

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