The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population

Jau Tsuen Kao, Keh Sung Tsai, Chih-Jen Chang, Po Chao Huang

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The effects of apolipoprotein E (apo E) polymorphism on the distribution of serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were studied in 546 unrelated Chinese in Taiwan. By isoelectric focusing and immunoblotting, three common alleles were demonstrated. The frequencies of the ε2, ε3 and ε4 alleles were 0.076, 0.875 and 0.049, respectively. The relative frequency of the ε3 allele was higher than that in Caucasians, whereas the frequency of ε4 was lower in the Chinese population. Individuals with apo E4 4 phenotype had the highest serum TC and LDL-C concentrations, while the lowest levels were associated with apo E2 2 phenotype. There was a trend for individuals carrying the ε2 allele to have a higher HDL-C level. No relationship between apo E phenotype and TG level was observed in this study. These data indicated that a given apo E allele acted in a relatively similar way in determining individual differences between Chinese and Caucasian populations in serum lipid and lipoprotein.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalAtherosclerosis
Volume114
Issue number1
DOIs
Publication statusPublished - 1995 Apr 7

Fingerprint

Apolipoproteins E
Lipoproteins
Alleles
Lipids
Phenotype
LDL Cholesterol
HDL Cholesterol
Population
Triglycerides
Serum
Cholesterol
Apolipoprotein E2
Apolipoprotein E4
Isoelectric Focusing
Taiwan
Immunoblotting
Gene Frequency
Individuality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{237fed490b5245d7a57306cd8bc10c35,
title = "The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population",
abstract = "The effects of apolipoprotein E (apo E) polymorphism on the distribution of serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were studied in 546 unrelated Chinese in Taiwan. By isoelectric focusing and immunoblotting, three common alleles were demonstrated. The frequencies of the ε2, ε3 and ε4 alleles were 0.076, 0.875 and 0.049, respectively. The relative frequency of the ε3 allele was higher than that in Caucasians, whereas the frequency of ε4 was lower in the Chinese population. Individuals with apo E4 4 phenotype had the highest serum TC and LDL-C concentrations, while the lowest levels were associated with apo E2 2 phenotype. There was a trend for individuals carrying the ε2 allele to have a higher HDL-C level. No relationship between apo E phenotype and TG level was observed in this study. These data indicated that a given apo E allele acted in a relatively similar way in determining individual differences between Chinese and Caucasian populations in serum lipid and lipoprotein.",
author = "Kao, {Jau Tsuen} and Tsai, {Keh Sung} and Chih-Jen Chang and Huang, {Po Chao}",
year = "1995",
month = "4",
day = "7",
doi = "10.1016/0021-9150(94)05464-T",
language = "English",
volume = "114",
pages = "55--59",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population. / Kao, Jau Tsuen; Tsai, Keh Sung; Chang, Chih-Jen; Huang, Po Chao.

In: Atherosclerosis, Vol. 114, No. 1, 07.04.1995, p. 55-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effects of apolipoprotein E polymorphism on the distribution of lipids and lipoproteins in the Chinese population

AU - Kao, Jau Tsuen

AU - Tsai, Keh Sung

AU - Chang, Chih-Jen

AU - Huang, Po Chao

PY - 1995/4/7

Y1 - 1995/4/7

N2 - The effects of apolipoprotein E (apo E) polymorphism on the distribution of serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were studied in 546 unrelated Chinese in Taiwan. By isoelectric focusing and immunoblotting, three common alleles were demonstrated. The frequencies of the ε2, ε3 and ε4 alleles were 0.076, 0.875 and 0.049, respectively. The relative frequency of the ε3 allele was higher than that in Caucasians, whereas the frequency of ε4 was lower in the Chinese population. Individuals with apo E4 4 phenotype had the highest serum TC and LDL-C concentrations, while the lowest levels were associated with apo E2 2 phenotype. There was a trend for individuals carrying the ε2 allele to have a higher HDL-C level. No relationship between apo E phenotype and TG level was observed in this study. These data indicated that a given apo E allele acted in a relatively similar way in determining individual differences between Chinese and Caucasian populations in serum lipid and lipoprotein.

AB - The effects of apolipoprotein E (apo E) polymorphism on the distribution of serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were studied in 546 unrelated Chinese in Taiwan. By isoelectric focusing and immunoblotting, three common alleles were demonstrated. The frequencies of the ε2, ε3 and ε4 alleles were 0.076, 0.875 and 0.049, respectively. The relative frequency of the ε3 allele was higher than that in Caucasians, whereas the frequency of ε4 was lower in the Chinese population. Individuals with apo E4 4 phenotype had the highest serum TC and LDL-C concentrations, while the lowest levels were associated with apo E2 2 phenotype. There was a trend for individuals carrying the ε2 allele to have a higher HDL-C level. No relationship between apo E phenotype and TG level was observed in this study. These data indicated that a given apo E allele acted in a relatively similar way in determining individual differences between Chinese and Caucasian populations in serum lipid and lipoprotein.

UR - http://www.scopus.com/inward/record.url?scp=0028958158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028958158&partnerID=8YFLogxK

U2 - 10.1016/0021-9150(94)05464-T

DO - 10.1016/0021-9150(94)05464-T

M3 - Article

VL - 114

SP - 55

EP - 59

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -