TY - JOUR
T1 - The elucidation of epinephrine as an antihypotensive agent in abamectin intoxication
AU - Hsu, Dur Zong
AU - Chiang, Po Jung
AU - Hsu, Ching Hung
AU - Huang, Bu Miin
AU - Deng, Jou Fang
AU - Liu, Ming Yie
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Abamectin (ABM) has been used in some suicidal attempt cases in recent years. ABM-intoxicated patients demonstrate low mean arterial pressure (MAP) and commonly treated with catecholamine to burst MAPs in their intensive cares. This investigation examined roles of epinephrine on MAP, heart rate (HR), and therein baroreflex sensitivity (BRS = HR/MAP) during ABM intoxication in rats. Oral application of ABM (20 mg/kg) induced an increase in HR and BRS accompanied by a decrease in MAP. These effects, except for on BRS, were abolished by concomitant epinephrine injection [100 μg/kg, subcutaneously (s.c.)]. ABM also induced an increase in serum nitric oxide levels, which was partly antagonized by epinephrine. In summary, oral application of ABM induced a decrease in MAP. Administration of epinephrine sustained the normal range of MAP via nitric oxide regulation, but it has no effect on BRS due to the synchronous changes of MAP and HR in ABM-intoxicated rats.
AB - Abamectin (ABM) has been used in some suicidal attempt cases in recent years. ABM-intoxicated patients demonstrate low mean arterial pressure (MAP) and commonly treated with catecholamine to burst MAPs in their intensive cares. This investigation examined roles of epinephrine on MAP, heart rate (HR), and therein baroreflex sensitivity (BRS = HR/MAP) during ABM intoxication in rats. Oral application of ABM (20 mg/kg) induced an increase in HR and BRS accompanied by a decrease in MAP. These effects, except for on BRS, were abolished by concomitant epinephrine injection [100 μg/kg, subcutaneously (s.c.)]. ABM also induced an increase in serum nitric oxide levels, which was partly antagonized by epinephrine. In summary, oral application of ABM induced a decrease in MAP. Administration of epinephrine sustained the normal range of MAP via nitric oxide regulation, but it has no effect on BRS due to the synchronous changes of MAP and HR in ABM-intoxicated rats.
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M3 - Article
C2 - 12948083
AN - SCOPUS:0041887029
SN - 0960-3271
VL - 22
SP - 433
EP - 437
JO - Human and Experimental Toxicology
JF - Human and Experimental Toxicology
IS - 8
ER -
