The estrogen receptor-β expression in de Quervain’s disease

Po Chuan Shen, Ping Hui Wang, Po-Ting Wu, Kuo Chen Wu, Jeng Long Hsieh, I. Ming Jou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Stenosing tenosynovitis of the first dorsal compartment of the wrist (a.k.a. de Quervain’s disease) is common but how estrogen is involved is still unknown. We previously reported that inflammation was involved in the pathogenesis of this ailment. In the present study, we extended our investigation of estrogen receptor (ER)-β expression to determine whether estrogen is involved in the pathogenesis of de Quervain’s. Intraoperative retinaculum samples were collected from 16 patients with the ailment. Specimens were histologically graded by collagen structure and immunohistochemically evaluated by quantifying the expression of ER-β, interleukin (IL)-1β and IL-6 (inflammatory cytokines), cyclooxygenase (COX)-2 (an inflammatory enzyme), and vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s occurs primarily in women. The female:male ratio in our study was 7:1. We found that ER-β expression in the retinaculum was positively correlated with disease grade and patient age. Additionally, disease severity was associated with inflammatory factors—IL-1β and IL-6, COX-2, and VEGF and vWF in tenosynovial tissue. The greater the levels of ER-β expression, tissue inflammation, and angiogenesis are, the more severe de Quervain’s disease is. ER-β might be a useful target for novel de Quervain’s disease therapy.

Original languageEnglish
Pages (from-to)26452-26462
Number of pages11
JournalInternational journal of molecular sciences
Volume16
Issue number11
DOIs
Publication statusPublished - 2015 Nov 4

Fingerprint

De Quervain Disease
estrogens
Estrogen Receptors
interleukins
von Willebrand Factor
Cyclooxygenase 2
Vascular Endothelial Growth Factor A
Interleukin-6
Tendon Entrapment
Estrogens
pathogenesis
Inflammation
Estrogen Receptor alpha
Tissue
Wrist
Interleukin-1
Collagen
wrist
angiogenesis
Cytokines

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Shen, Po Chuan ; Wang, Ping Hui ; Wu, Po-Ting ; Wu, Kuo Chen ; Hsieh, Jeng Long ; Jou, I. Ming. / The estrogen receptor-β expression in de Quervain’s disease. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 11. pp. 26452-26462.
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The estrogen receptor-β expression in de Quervain’s disease. / Shen, Po Chuan; Wang, Ping Hui; Wu, Po-Ting; Wu, Kuo Chen; Hsieh, Jeng Long; Jou, I. Ming.

In: International journal of molecular sciences, Vol. 16, No. 11, 04.11.2015, p. 26452-26462.

Research output: Contribution to journalArticle

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