The feasibility of anterior 180° 99m Tc-sestamibi parathyroid SPECT/CT

Ju Ling Cheng, Chien Chin Hsu, Pei Wen Wang, Kuo Chiang Sung, Nan Tsing Chiu, Lan Yi Chiu, Yung Cheng Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objective: For 99mTc-sestamibi parathyroid single photon emission computed tomography/computed tomography (SPECT/CT), the traditional full-arc 360° acquisition technique has been suggested but not the theoretically low tissue-attenuated anterior 180° method. We aimed to compare the diagnostic performances and target-to-background ratios of anterior 180° and 360° SPECT/CT imaging. Methods: Ninety-nine patients who underwent 99mTc-sestamibi scintigraphy and received a surgical–pathological diagnosis of parathyroid adenoma or hyperplasia were enrolled. The SPECT/CT reconstructed images with anterior 180° and full-arc 360° data were interpreted by two physicians using a scoring scale, and the lesions were semi-quantified using target-to-background ratios for both image sets. Results: In total, 113 abnormal parathyroid lesions were identified on the SPECT/CT images. The agreements of interpretation between the two image sets and readers were very good (κ value: 0.83–1.00). The accuracies of summative interpretation for the anterior 180° and full-arc 360° SPECT/CT were 83.04% and 82.46%, respectively. The target-to-background ratios were significantly higher for the anterior 180° than the full-arc 360° images (P < 0.01). Conclusions: The anterior 180° SPECT/CT technique, a time-saving method, can provide satisfactory diagnostic performance and superior lesion contrast compared with the full-arc 360° SPECT/CT technique in 99mTc-sestamibi parathyroid imaging.

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalAnnals of Nuclear Medicine
Issue number2
Publication statusPublished - 2021 Feb

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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