The first isolation of an acridone alkaloid from poncirus trifoliata

Tian Shung Wu, Ru Jin Cheng, Shiow Chyn Huang, Hiroshi Furukawa

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9 Citations (Scopus)


Poncirus trifoliata (L.) Raf. (Rutaceae) is the original plant of the traditional Chinese medicine “Gou Ju,” which has been used for treating pain, stomach ache, hysteroptosis, stagnant blood, and as a detoxicant of wine poisoning (1). The presence of an essential oil, coumarins, and flavonoids in this plant has been reported (2-9). However, no alkaloidal component has been detected in this plant. In the course of our studies on the isolation of the acridone alkaloids in the Rutaceae, we have reinvestigated the constituents of this plant and identified the acridone alkaloid, 5-hydroxynoracronycine, in the root bark. This is the first example of the isolation of an acridone alkaloid from the genus Poncirus. Coumarins, poncitrin (dentatin), nordentatin, and marmesin, were also identified.

Original languageEnglish
Pages (from-to)1154-1155
Number of pages2
JournalJournal of Natural Products
Issue number6
Publication statusPublished - 1986

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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