The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor

Chi Chung Peng, Hui Tzu Sun, I. Ping Lin, Ping-Chung Kuo, Jen Chieh Li

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5%, 1% and 2% of 10-HDA onto the skin of mice (C57BL/6J) for 3week to observe the effect of DL*-values. Results: The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions: The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products.

Original languageEnglish
Article number392
JournalBMC Complementary and Alternative Medicine
Volume17
Issue number1
DOIs
Publication statusPublished - 2017 Aug 9

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Melanins
Microphthalmia-Associated Transcription Factor
Melanoma
Skin
Monophenol Monooxygenase
Skin Pigmentation
Skin Care
10-hydroxy-2-decenoic acid
royal jelly
Proteins
Bees
Inbred C57BL Mouse
Cosmetics
Inhibitory Concentration 50
Western Blotting

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

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title = "The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor",
abstract = "Background: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5{\%}, 1{\%} and 2{\%} of 10-HDA onto the skin of mice (C57BL/6J) for 3week to observe the effect of DL*-values. Results: The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions: The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products.",
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The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor. / Peng, Chi Chung; Sun, Hui Tzu; Lin, I. Ping; Kuo, Ping-Chung; Li, Jen Chieh.

In: BMC Complementary and Alternative Medicine, Vol. 17, No. 1, 392, 09.08.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor

AU - Peng, Chi Chung

AU - Sun, Hui Tzu

AU - Lin, I. Ping

AU - Kuo, Ping-Chung

AU - Li, Jen Chieh

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N2 - Background: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5%, 1% and 2% of 10-HDA onto the skin of mice (C57BL/6J) for 3week to observe the effect of DL*-values. Results: The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions: The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products.

AB - Background: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5%, 1% and 2% of 10-HDA onto the skin of mice (C57BL/6J) for 3week to observe the effect of DL*-values. Results: The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions: The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products.

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