The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins

Weiping Peng; Gail Henderson; Guey Chuen Perng; Anthony B. Nesburn; Steven L. Wechsler; Clinton Jones

doi:10.1128/JVI.77.19.10714-10718.2003

The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x_L and Bcl-x_S) that encode apoptotic regulatory proteins

Weiping Peng, Gail Henderson, Guey Chuen Perng, Anthony B. Nesburn, Steven L. Wechsler, Clinton Jones

Institute of Basic Medical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x_L transcript versus the Bcl-x_S transcript in Neuro-2A cells. Bcl-x_L encodes an antiapoptotic protein, whereas Bcl-x_S encodes a proapoptotic protein. Promoting the accumulation of Bcl-x_L in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

Original language	English
Pages (from-to)	10714-10718
Number of pages	5
Journal	Journal of Virology
Volume	77
Issue number	19
DOIs	https://doi.org/10.1128/JVI.77.19.10714-10718.2003
Publication status	Published - 2003 Oct

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.77.19.10714-10718.2003

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Peng, W., Henderson, G., Perng, G. C., Nesburn, A. B., Wechsler, S. L., & Jones, C. (2003). The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x_L and Bcl-x_S) that encode apoptotic regulatory proteins. Journal of Virology, 77(19), 10714-10718. https://doi.org/10.1128/JVI.77.19.10714-10718.2003

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title = "The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins",

abstract = "The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.",

author = "Weiping Peng and Gail Henderson and Perng, {Guey Chuen} and Nesburn, {Anthony B.} and Wechsler, {Steven L.} and Clinton Jones",

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language = "English",

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Peng, W, Henderson, G, Perng, GC, Nesburn, AB, Wechsler, SL & Jones, C 2003, 'The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x_L and Bcl-x_S) that encode apoptotic regulatory proteins', Journal of Virology, vol. 77, no. 19, pp. 10714-10718. https://doi.org/10.1128/JVI.77.19.10714-10718.2003

The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x_L and Bcl-x_S) that encode apoptotic regulatory proteins. / Peng, Weiping; Henderson, Gail; Perng, Guey Chuen et al.
In: Journal of Virology, Vol. 77, No. 19, 10.2003, p. 10714-10718.

Research output: Contribution to journal › Article › peer-review

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T1 - The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins

AU - Peng, Weiping

AU - Henderson, Gail

AU - Perng, Guey Chuen

AU - Nesburn, Anthony B.

AU - Wechsler, Steven L.

AU - Jones, Clinton

PY - 2003/10

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N2 - The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

AB - The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.

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The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x_L and Bcl-x_S) that encode apoptotic regulatory proteins

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