The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of encephalitis in male BALB/c mice

Clinton Jones, Melissa Inman, Weiping Peng, Gail Henderson, Alan Doster, Guey Chuen Perng, Anisa Kaenjak Angeletti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes thai regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.

Original languageEnglish
Pages (from-to)14465-14469
Number of pages5
JournalJournal of Virology
Volume79
Issue number22
DOIs
Publication statusPublished - 2005 Nov

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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