The homozygote AA genotype of the α 1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women

J. J. Lin, K. C. Yueh, C. Y. Chang, Chih-Hung Chen, S. Z. Lin

Research output: Contribution to journalArticle

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Abstract

There has been increasing evidence suggesting that inflammatory response maybe involved in the pathogenesis of Parkinson's disease (PD). α 1-Antichymotrypsin gene (ACT) has been regarded as a susceptibility factor for PD in the past, but the evidence remains controversial. This case-control study was designed to investigate the association of α 1-antichymotrypsin gene (ACT) polymorphism between 210 Taiwanese patients with clinical definite sporadic PD and 260 controls, matched by age and sex. There were no differences of allelic frequency (A and T) and genotype polymorphism (AA, AT and TT) of the ACT in PD patients from the controls. However, there were significantly fewer early-onset PD (onset age younger than 60 years) or PD women carrying the homozygote AA genotype (ACT-AA) than in controls (p=0.046 and 0.044, respectively). Further analysis revealed that the reduced risk of ACT-AA was particularly significant among PD women with the onset age younger than 60 years (OR=0.796, 95% CI=0.749-0.847, p<0.0001). This study shows that ACT-AA may confer a modest protection against developing early-onset PD in women.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalParkinsonism and Related Disorders
Volume10
Issue number8
DOIs
Publication statusPublished - 2004 Dec 1

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Homozygote
Parkinson Disease
Genotype
Genes
Age of Onset
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

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title = "The homozygote AA genotype of the α 1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women",
abstract = "There has been increasing evidence suggesting that inflammatory response maybe involved in the pathogenesis of Parkinson's disease (PD). α 1-Antichymotrypsin gene (ACT) has been regarded as a susceptibility factor for PD in the past, but the evidence remains controversial. This case-control study was designed to investigate the association of α 1-antichymotrypsin gene (ACT) polymorphism between 210 Taiwanese patients with clinical definite sporadic PD and 260 controls, matched by age and sex. There were no differences of allelic frequency (A and T) and genotype polymorphism (AA, AT and TT) of the ACT in PD patients from the controls. However, there were significantly fewer early-onset PD (onset age younger than 60 years) or PD women carrying the homozygote AA genotype (ACT-AA) than in controls (p=0.046 and 0.044, respectively). Further analysis revealed that the reduced risk of ACT-AA was particularly significant among PD women with the onset age younger than 60 years (OR=0.796, 95{\%} CI=0.749-0.847, p<0.0001). This study shows that ACT-AA may confer a modest protection against developing early-onset PD in women.",
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The homozygote AA genotype of the α 1-antichymotrypsin gene may confer protection against early-onset Parkinson's disease in women. / Lin, J. J.; Yueh, K. C.; Chang, C. Y.; Chen, Chih-Hung; Lin, S. Z.

In: Parkinsonism and Related Disorders, Vol. 10, No. 8, 01.12.2004, p. 469-473.

Research output: Contribution to journalArticle

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