The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan

Tsung Hsien Lin, Shao Yuan Chuang, Chun Yuan Chu, Wen Hsien Lee, Po Chao Hsu, Ho Ming Su, Yi Heng Li, Ching Chang Fang, Kuo Yang Wang, Wei Kung Tseng, Ai Hsien Li, Kwo Chang Ueng, I. Chang Hsieh, Lien Chi Huang, Chiun Hsiung Wang, Wen Harn Pan, Hung I. Yeh, Chau Chung Wu, Wei Hsian Yin, Jaw Wen Chen

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Abstract

Background: Patients with chronic kidney disease (CKD) is a very high risk cardiovascular disease population and should be treated aggressively. We investigated lipid management in CKD patients with atherosclerosis in Taiwan. Methods: 3057 patients were enrolled in a multi-center study (T-SPARCLE). Lipid goal are defined as total cholesterol (TC) < 160mg/dl, low-density lipoprotein (LDL) <100 mg/dl, high-density lipoprotein (HDL) > 40 mg/dl in men, HDL > 50 mg/dl in women, non-HDL cholesterol < 130mg/dl, and triglyceride < 150 mg/dl. Results: Compared with those without CKD (n=2239), patients with CKD (n=818) had more co-morbidities (hypertension, glucose intolerance, stroke and heart failure) and lower HDL but higher triglyceride levels. Overall 2168 (70.5%) patients received lipid-lowering agents. There was similar equivalent statin potency between CKD and non-CKD groups. The goal attainment is lower in HDL and TG in the CKD group as compared with non-CKD subjects (47.1 vs. 51.9% and 63.2 vs. 68.9% respectively, both p < 0.02). Analysis of sex and CKD interaction on goals attainment showed female CKD subjects had lower non-HDL and TG goals attainment compared with non-CKD males (both p < 0.019). Conclusion: Although presenting with more comorbidities, the CKD population had suboptimal lipid goal attainment rate as compared with the non-CKD population. Further efforts may be required for better lipid control especially on the female CKD subjects.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalInternational Journal of Medical Sciences
Volume11
Issue number4
DOIs
Publication statusPublished - 2014 Feb 20

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Lin, T. H., Chuang, S. Y., Chu, C. Y., Lee, W. H., Hsu, P. C., Su, H. M., Li, Y. H., Fang, C. C., Wang, K. Y., Tseng, W. K., Li, A. H., Ueng, K. C., Hsieh, I. C., Huang, L. C., Wang, C. H., Pan, W. H., Yeh, H. I., Wu, C. C., Yin, W. H., & Chen, J. W. (2014). The impact of chronic kidney disease on lipid management and goal attainment in patients with atherosclerosis diseases in Taiwan. International Journal of Medical Sciences, 11(4), 381-388. https://doi.org/10.7150/ijms.7069