The impact of permanent pacemaker implantation on thallium myocardial perfusion examination detecting ischemic heart disease

Mu Shiang Huang, Tse Wei Chen, Yi Sheng Liu, Yi Shen Wang, Cheng Han Lee, Ju Yi Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Patients with permanent pacemaker (PPM) implantation may have altered coronary perfusion patterns that may influence the accuracy of myocardial perfusion examination modalities, which was observed in previous studies but with limited statistic power. Our aim was to examine the performance of thallium-201 (TL-201) myocardial perfusion examination in patients with implanted PPM. Methods Data of consecutive patients from our institution who had coronary angiography examination followed by TL-201 myocardial perfusion examination in pairs within 1 year were collected between January 2010 and December 2016 and were divided into PPM and control groups. Propensity score matching (PSM) was performed to compare the positive predictive value (PPV) of perfusion examinations. Results A total of 934 pairs of studies were evaluated, with 81 in the PPM group and 853 controls. The PPV decreased significantly in the PPM group (28.2 vs. 62.9%, P < 0.001). The finding of large (>20%) ischemic areas correlated significantly with all-cause mortality in the control group (OR, 2.34; P = 0.001), but not in the PPM group (OR,1.05; P = 0.943). After PSM, the PPV was still significantly lower in the PPM group than in the non-PPM group (28.6 vs. 66.2%, P < 0.001). Conclusion Study results do not support the appropriateness of using TL-201 perfusion examinations for risk stratification in patients with implanted PPM. Video Abstract: http://links.lww.com/NMC/A181.

Original languageEnglish
Pages (from-to)190-197
Number of pages8
JournalNuclear Medicine Communications
DOIs
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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