The importance of hematopoietic progenitor cells in dengue

Jih Jin Tsai, L. Teh Liu, Ko Chang, Shu Hui Wang, Hui Mien Hsiao, Kristina B. Clark, Guey-Chuen Perng

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Scientific investigations designed to better understand and assess the distinguishing clinical characteristics pave the way to a successful treatment for a disease. Since the peripheral blood is obtained easily, the most frequent type of investigation performed on infectious agents focuses on the hematological components of blood drawn from patients. Bone marrow aspirates, although somewhat more difficult to obtain, should be evaluated more frequently because they provide additional information, giving us a glimpse into the development of the disease. Understanding the distinct and unique changes in hematological components of the bone marrow induced by a particular pathogen or corresponding to a specific illness may be a valuable asset for the diagnosis and prognosis of disease. A good example of a pathogen that could be better evaluated with greater knowledge of the bone marrow is dengue, one of the most important public vector-borne human diseases. Owing to the multitude of clinical manifestations and the dynamic alterations of various blood components over time, this disease is one of the most difficult to prevent and treat in humans. Although large amounts of data have been generated in the literature, there remains a large gap between this information and its relevance for the purpose of patient care. While evaluating the cellular components in the circulated blood from ill patients provides us with valuable information about the pathogenesis of various pathogens, there are other players participating in the progression to disease. The goal of this review is to emphasize the importance of bone marrow hematopoietic progenitor cells in disease and to inspire other researchers to incorporate them into their investigations on dengue pathogenesis. It is anticipated that the knowledge derived from these investigations not only elicit original concepts on the pathogenesis of dengue but also foster a new way of thinking in terms of vaccine or therapeutic development to prevent and treat dengue.

Original languageEnglish
Pages (from-to)59-71
Number of pages13
JournalTherapeutic Advances in Hematology
Volume3
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Dengue
Hematopoietic Stem Cells
Bone Marrow
Disease Progression
Patient Care
Vaccines
Research Personnel
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Tsai, J. J., Liu, L. T., Chang, K., Wang, S. H., Hsiao, H. M., Clark, K. B., & Perng, G-C. (2012). The importance of hematopoietic progenitor cells in dengue. Therapeutic Advances in Hematology, 3(1), 59-71. https://doi.org/10.1177/2040620711417660
Tsai, Jih Jin ; Liu, L. Teh ; Chang, Ko ; Wang, Shu Hui ; Hsiao, Hui Mien ; Clark, Kristina B. ; Perng, Guey-Chuen. / The importance of hematopoietic progenitor cells in dengue. In: Therapeutic Advances in Hematology. 2012 ; Vol. 3, No. 1. pp. 59-71.
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Tsai, JJ, Liu, LT, Chang, K, Wang, SH, Hsiao, HM, Clark, KB & Perng, G-C 2012, 'The importance of hematopoietic progenitor cells in dengue', Therapeutic Advances in Hematology, vol. 3, no. 1, pp. 59-71. https://doi.org/10.1177/2040620711417660

The importance of hematopoietic progenitor cells in dengue. / Tsai, Jih Jin; Liu, L. Teh; Chang, Ko; Wang, Shu Hui; Hsiao, Hui Mien; Clark, Kristina B.; Perng, Guey-Chuen.

In: Therapeutic Advances in Hematology, Vol. 3, No. 1, 01.01.2012, p. 59-71.

Research output: Contribution to journalReview article

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Tsai JJ, Liu LT, Chang K, Wang SH, Hsiao HM, Clark KB et al. The importance of hematopoietic progenitor cells in dengue. Therapeutic Advances in Hematology. 2012 Jan 1;3(1):59-71. https://doi.org/10.1177/2040620711417660