The incidence and risk factors of hepatic veno-occlusive disease after hematopoietic stem cell transplantation in Taiwan

Chien Chang Lee, Hsiu Hao Chang, Meng Yao Lu, Yung Li Yang, Shu Wei Chou, Dong Tsamn Lin, Shiann Tarng Jou, Ming Yao, Chi Cheng Li, Su Peng Yeh, Mei Hui Chen, Jyh Pyng Gau, Sin Syue Li, Po Nan Wang, Yi Chang Liu, Tso Fu Wang, Tran Der Tan, Ming Yang Lee, Ming Sun Yu, Chuan Cheng WangShih Chiang Lin, Yeu Chin Chen, Yung Cheng Su, Ko Ying Su, Kai Hsin Lin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Hepatic veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). We conducted this study to investigate the incidence and risk factors of hepatic VOD for patients receiving HSCT in Taiwan. We retrospectively analyzed the data from a nationwide registry for patients receiving HSCT, which was collected by the Taiwan Society of Blood and Marrow Transplantation. The data collection period was from 2009 to 2014. A total 2345 patients were reviewed and 39 patients among them were diagnosed as having hepatic VOD. The cumulative incidence of hepatic VOD in the whole cohort of 2345 patients was 1.66%. In multivariate analysis, disease diagnosis of myelodysplastic syndrome, chronic HCV infection, condition regimens of bulsulfan intravenously administered, and antithymocyte immunoglobulin were independent factors to predict higher risk of hepatic VOD. The overall mortality rate for patients with hepatic VOD was 79%. Patients with hepatic VOD had significant worse survival outcomes when compared with those without hepatic VOD (P = 0.00063). In conclusion, although the incidence is low, hepatic VOD remains a serious complication after HSCT in Taiwan. The findings of this study could be the basis for developing prophylactic or early treatment strategies for hepatic VOD.

Original languageEnglish
Pages (from-to)745-752
Number of pages8
JournalAnnals of Hematology
Issue number3
Publication statusPublished - 2019 Mar 4

All Science Journal Classification (ASJC) codes

  • Hematology


Dive into the research topics of 'The incidence and risk factors of hepatic veno-occlusive disease after hematopoietic stem cell transplantation in Taiwan'. Together they form a unique fingerprint.

Cite this