The influence of acute hyperglycemia in an animal model of lacunar stroke that is induced by artificial particle embolization

Ming Jun Tsai, Ming Wei Lin, Yaw Bin Huang, Yu Min Kuo, Yi Hung Tsai

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Animal and clinical studies have revealed that hyperglycemia during ischemic stroke increases the stroke’s severity and the infarct size in clinical and animal studies. However, no conclusive evidence demonstrates that acute hyperglycemia worsens post-stroke outcomes and increases infarct size in lacunar stroke. In this study, we developed a rat model of lacunar stroke that was induced via the injection of artificial embolic particles during full consciousness. We then used this model to compare the acute influence of hyperglycemia in lacunar stroke and diffuse infarction, by evaluating neurologic behavior and the rate, size, and location of the infarction. The time course of the neurologic deficits was clearly recorded from immediately after induction to 24 h post-stroke in both types of stroke. We found that acute hyperglycemia aggravated the neurologic deficit in diffuse infarction at 24 h after stroke, and also aggravated the cerebral infarct. Furthermore, the infarct volumes of the basal ganglion, thalamus, hippocampus, and cerebellum but not the cortex were positively correlated with serum glucose levels. In contrast, acute hyperglycemia reduced the infarct volume and neurologic symptoms in lacunar stroke within 4 min after stroke induction, and this effect persisted for up to 24 h post-stroke. In conclusion, acute hyperglycemia aggravated the neurologic outcomes in diffuse infarction, although it significantly reduced the size of the cerebral infarct and improved the neurologic deficits in lacunar stroke.

Original languageEnglish
Pages (from-to)347-356
Number of pages10
JournalInternational Journal of Medical Sciences
Volume13
Issue number5
DOIs
Publication statusPublished - 2016 Apr 27

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'The influence of acute hyperglycemia in an animal model of lacunar stroke that is induced by artificial particle embolization'. Together they form a unique fingerprint.

Cite this