The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

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Abstract

Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

Original languageEnglish
Pages (from-to)248-257
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume28
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Head and Neck Neoplasms
Alcohol Drinking
Ethanol
Survival
Genes
Alcohols
Mouth Neoplasms
Hypopharyngeal Neoplasms
Oropharyngeal Neoplasms
Laryngeal Neoplasms
Proportional Hazards Models
Genotype

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

@article{5300a8bd58584b338d217c4bb457cc49,
title = "The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients",
abstract = "Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.",
author = "Wei-Ting Lee and Jenn-Ren Hsiao and Chun-Yen Ou and Cheng-Chih Huang and Chan-Chi Chang and Sen-Tien Tsai and Ken-Chung Chen and Jehn-Shun Huang and Dung-Yau Wang and Yu-Hsuan Lai and Yuan-Hua Wu and Wei-Ting Hsueh and Shang-Yin Wu and Chia-Jui Yen and Jang-Yang Chang and Lin, {Chen Lin} and Weng, {Ya Ling} and Yang, {Han Chien} and Chen, {Yu Shan} and Chang, {Jeffrey S.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1158/1055-9965.EPI-18-0425",
language = "English",
volume = "28",
pages = "248--257",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
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TY - JOUR

T1 - The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients

AU - Lee, Wei-Ting

AU - Hsiao, Jenn-Ren

AU - Ou, Chun-Yen

AU - Huang, Cheng-Chih

AU - Chang, Chan-Chi

AU - Tsai, Sen-Tien

AU - Chen, Ken-Chung

AU - Huang, Jehn-Shun

AU - Wang, Dung-Yau

AU - Lai, Yu-Hsuan

AU - Wu, Yuan-Hua

AU - Hsueh, Wei-Ting

AU - Wu, Shang-Yin

AU - Yen, Chia-Jui

AU - Chang, Jang-Yang

AU - Lin, Chen Lin

AU - Weng, Ya Ling

AU - Yang, Han Chien

AU - Chen, Yu Shan

AU - Chang, Jeffrey S.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

AB - Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pretreatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between prediagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. Results: The results showed a significant positive dose-response relationship between prediagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/ nonfunctional ALDH2 genotype combination. Conclusions: Our analysis showed a significant positive dose-response relationship between prediagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol-metabolizing genes, ADH1B and ALDH2, modified the relationship between prediagnosis alcohol use and the OS of HNC patients. Impact: Prediagnosis alcohol use may be a prognostic indicator of HNC.

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U2 - 10.1158/1055-9965.EPI-18-0425

DO - 10.1158/1055-9965.EPI-18-0425

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VL - 28

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JO - Cancer Epidemiology Biomarkers and Prevention

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SN - 1055-9965

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