TY - GEN
T1 - The influence of surface morphology and rigidity of the substrata on cell motility
AU - Chen, W. C.
AU - Hsieh, P. C.
AU - Wang, G. M.
AU - Yeh, M. L.
N1 - Funding Information:
The authors would like to thank the assistance in microelectromechanical system and SEM from National Nano Device Laboratory of Taiwan and the financial support from the Southern Division of Industrial Technology Research of Taiwan (ITRI-FY96). We also appreciate support of the instruments from professors Fong-Chin Su and Hsian-Chang Chang at the Institute of Biomedical Engineering of National Cheng Kung University of Taiwan.
PY - 2009
Y1 - 2009
N2 - Physical factors like stiffness and surface morphology of the substrata are thought to influence cell behaviors. How the cell motility at early attachment influenced by the substrates was not investigated yet. The purpose of this study is to measure the cell motility under different stiffness and pattern of the substrata. PDMS groups moved significant faster than glass due to smaller stiffness. In addition, over 80% of cells on long groove PDMS moved along the groove, indicating long groove was the best surface morphology to control cell directional movement.
AB - Physical factors like stiffness and surface morphology of the substrata are thought to influence cell behaviors. How the cell motility at early attachment influenced by the substrates was not investigated yet. The purpose of this study is to measure the cell motility under different stiffness and pattern of the substrata. PDMS groups moved significant faster than glass due to smaller stiffness. In addition, over 80% of cells on long groove PDMS moved along the groove, indicating long groove was the best surface morphology to control cell directional movement.
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U2 - 10.1109/NEBC.2009.4967790
DO - 10.1109/NEBC.2009.4967790
M3 - Conference contribution
AN - SCOPUS:70349150192
SN - 9781424443628
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
BT - NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Y2 - 3 April 2009 through 5 April 2009
ER -