The influence of verapamil and nifedipine on hepatic indocyanine green clearance in patients with HBsAg-positive cirrhosis and ascites

Chii Shyan Lay, Yang Te Tsai, Chi Woon Kong, Fa Yauh Lee, Ting-Tsung Chang, Han Chieh Lin, Chuen May Yang, Shou Dong Lee, Benjamin N. Chiang, Kwang Juei Lo

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Abstract

The influence of verapamil and nifedipine on hepatic indocyanine green kinetics was studied in 12 patients with HBsAg-positive cirrhosis and ascites. Hepatic clearance and its two biologic determinants, hepatic blood flow and metabolic activity (intrinsic clearance [maximum velocity/metabolite elimination rate constant, or Vmax/km]), were determined from hepatic indocyanine green elimination at steady state in patients with cirrhosis. Acute intravenous administration 10 mg verapamil significantly increased the hepatic indocyanine green blood flow (p < 0.05), but significantly decreased the hepatic clearance (p < 0.05, extraction ratio (p < 0.05) and Vmax/km (p < 0.05. However, acute sublingual administration of 10 mg nifedipine resulted in no significant change in any parameters of hepatic elimination function. These results show that verapamil, but not nifedipine, might impair the transhepatic extraction activity of hepatocytes in patients with HBsAg-positive cirrhosis and ascites.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume44
Issue number4
DOIs
Publication statusPublished - 1988 Jan 1

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Indocyanine Green
Nifedipine
Hepatitis B Surface Antigens
Verapamil
Ascites
Fibrosis
Liver
Sublingual Administration
Intravenous Administration
Hepatocytes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Lay, Chii Shyan ; Tsai, Yang Te ; Kong, Chi Woon ; Lee, Fa Yauh ; Chang, Ting-Tsung ; Lin, Han Chieh ; Yang, Chuen May ; Lee, Shou Dong ; Chiang, Benjamin N. ; Lo, Kwang Juei. / The influence of verapamil and nifedipine on hepatic indocyanine green clearance in patients with HBsAg-positive cirrhosis and ascites. In: Clinical Pharmacology and Therapeutics. 1988 ; Vol. 44, No. 4. pp. 453-457.
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The influence of verapamil and nifedipine on hepatic indocyanine green clearance in patients with HBsAg-positive cirrhosis and ascites. / Lay, Chii Shyan; Tsai, Yang Te; Kong, Chi Woon; Lee, Fa Yauh; Chang, Ting-Tsung; Lin, Han Chieh; Yang, Chuen May; Lee, Shou Dong; Chiang, Benjamin N.; Lo, Kwang Juei.

In: Clinical Pharmacology and Therapeutics, Vol. 44, No. 4, 01.01.1988, p. 453-457.

Research output: Contribution to journalArticle

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AU - Lay, Chii Shyan

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AU - Chang, Ting-Tsung

AU - Lin, Han Chieh

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AU - Lee, Shou Dong

AU - Chiang, Benjamin N.

AU - Lo, Kwang Juei

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N2 - The influence of verapamil and nifedipine on hepatic indocyanine green kinetics was studied in 12 patients with HBsAg-positive cirrhosis and ascites. Hepatic clearance and its two biologic determinants, hepatic blood flow and metabolic activity (intrinsic clearance [maximum velocity/metabolite elimination rate constant, or Vmax/km]), were determined from hepatic indocyanine green elimination at steady state in patients with cirrhosis. Acute intravenous administration 10 mg verapamil significantly increased the hepatic indocyanine green blood flow (p < 0.05), but significantly decreased the hepatic clearance (p < 0.05, extraction ratio (p < 0.05) and Vmax/km (p < 0.05. However, acute sublingual administration of 10 mg nifedipine resulted in no significant change in any parameters of hepatic elimination function. These results show that verapamil, but not nifedipine, might impair the transhepatic extraction activity of hepatocytes in patients with HBsAg-positive cirrhosis and ascites.

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