The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia

For Wey Lung, Ming Chang Yang, Bih Ching Shu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A total of 934 patients with schizophrenia and 433 controls were genotyped for the interleukin-10 (IL-10) promoter and DRD4 uVNTR polymorphisms. DRD4 long-form variants (namely, those with ≥ 5 repeats), homozygosity for the 4-repeat allele, and the IL-10 haplotype ACA were associated with schizophrenia, respectively. No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.

Original languageEnglish
Pages (from-to)294-296
Number of pages3
JournalPsychiatry Research
Volume188
Issue number2
DOIs
Publication statusPublished - 2011 Jul 30

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia'. Together they form a unique fingerprint.

  • Cite this