The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: The Tianliao Old People (TOP) study 03

Chia Ling Chang, Po Tseng Lee, Wei Ting Chang, Chin Sung Chang, Jyh Hong Chen, Liang Miin Tsai, Chih Hsing Wu, Ping Yen Liu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

Original languageEnglish
Article number60
JournalDiabetology and Metabolic Syndrome
Volume5
Issue number1
DOIs
Publication statusPublished - 2013 Oct 16

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this