The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: The Tianliao Old People (TOP) study 03

Chia Ling Chang, Po-Tseng Lee, Wei Ting Chang, Chin-Sung Chang, Jyh Hong Chen, Liang-Miin Tsai, Chih-Hsing Wu, Ping-Yen Liu

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Abstract

Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

Original languageEnglish
Article number60
JournalDiabetology and Metabolic Syndrome
Volume5
Issue number1
DOIs
Publication statusPublished - 2013 Oct 16

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Taiwan
Geriatrics
Exercise
Inflammation
C-Reactive Protein

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{4c648ea600294d439fd2439af0fa2fca,
title = "The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan: The Tianliao Old People (TOP) study 03",
abstract = "Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8{\%} in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95{\%} CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95{\%} CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95{\%} IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.",
author = "Chang, {Chia Ling} and Po-Tseng Lee and Chang, {Wei Ting} and Chin-Sung Chang and Chen, {Jyh Hong} and Liang-Miin Tsai and Chih-Hsing Wu and Ping-Yen Liu",
year = "2013",
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doi = "10.1186/1758-5996-5-60",
language = "English",
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TY - JOUR

T1 - The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan

T2 - The Tianliao Old People (TOP) study 03

AU - Chang, Chia Ling

AU - Lee, Po-Tseng

AU - Chang, Wei Ting

AU - Chang, Chin-Sung

AU - Chen, Jyh Hong

AU - Tsai, Liang-Miin

AU - Wu, Chih-Hsing

AU - Liu, Ping-Yen

PY - 2013/10/16

Y1 - 2013/10/16

N2 - Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

AB - Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.

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