Abstract
Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.
| Original language | English |
|---|---|
| Article number | 60 |
| Journal | Diabetology and Metabolic Syndrome |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 Oct 16 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
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The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan : The Tianliao Old People (TOP) study 03. / Chang, Chia Ling; Lee, Po-Tseng; Chang, Wei Ting; Chang, Chin-Sung; Chen, Jyh Hong; Tsai, Liang-Miin; Wu, Chih-Hsing; Liu, Ping-Yen.
In: Diabetology and Metabolic Syndrome, Vol. 5, No. 1, 60, 16.10.2013.Research output: Contribution to journal › Article
TY - JOUR
T1 - The interplay between inflammation, physical activity and metabolic syndrome in a remote male geriatric community in Southern Taiwan
T2 - The Tianliao Old People (TOP) study 03
AU - Chang, Chia Ling
AU - Lee, Po-Tseng
AU - Chang, Wei Ting
AU - Chang, Chin-Sung
AU - Chen, Jyh Hong
AU - Tsai, Liang-Miin
AU - Wu, Chih-Hsing
AU - Liu, Ping-Yen
PY - 2013/10/16
Y1 - 2013/10/16
N2 - Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.
AB - Background: Both physical activity and inflammation are important in the pathophysiology of metabolic syndrome (MetS). Our study aim is to explore their associations in an elderly male (≥ 65 years old) cohort. Methods. We enrolled 309 elderly male residents (mean age: 74.4 ± 6.0 years) in a remote southern Taiwan community. The physical activity was recorded by a standard questionnaire. A high-sensitivity C-reactive protein (hsCRP) level > 3.0 mg/L indicated a high inflammatory status. Results: The total prevalence rate of MetS was 27.8% in this male geriatric cohort. Median hsCRP levels were significantly higher in the MetS group (1.60 ± 0.7 vs. 1.0 ± 0.3 mg/L, p < 0.01), and the risk of elevated hsCRP increased with escalating MetS components (p for trend < 0.001). The non-MetS group had higher amount of median weekly physical activity (183.1 ± 19.0 vs. 173.5 ± 10.6 MET-hr/week, p = 0.029), which was also higher among those with lower hsCRP levels (186.1 ± 14.1 vs. 167.8 ± 38.5 MET-hr/week, p = 0.013). Multivariate analysis showed that higher body mass index (ORs: 1.527, 95% CI: 1.319-1.768, p < 0.01) insulin (OR: 1.128, 95% CI: 1.045-1.218, p < 0.01) and physical activity (ORs: 0.997, 95% IC: 0.994-0.999, p < 0.05) were independent predictors of MetS, but not hsCRP level (p > 0.05). Conclusions: Reduced physical activity was one major pathophysiological MetS factor in our Asian geriatric participants.
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U2 - 10.1186/1758-5996-5-60
DO - 10.1186/1758-5996-5-60
M3 - Article
AN - SCOPUS:84885337843
VL - 5
JO - Diabetology and Metabolic Syndrome
JF - Diabetology and Metabolic Syndrome
SN - 1758-5996
IS - 1
M1 - 60
ER -