TY - JOUR
T1 - The involvement of PTEN in sleep deprivation-induced memory impairment in rats
AU - Su, Chun Lin
AU - Chen, Chun Hung
AU - Lu, Hsin Yi
AU - Gean, Po-Wu
PY - 2004/11/1
Y1 - 2004/11/1
N2 - Although the underlying mechanism is not elucidated, it has been postulated repeatedly that deprivation of sleep, particularly rapid eye movement (REM) sleep, affects learning. Here we report that memory for newly acquired information is impaired after a specific period of REM sleep deprivation (REMD). Memory retrieval-induced phosphorylation of protein kinases in the rat amygdala is abrogated by REMD that is associated with an increase in the expression of a dual protein/lipid phosphatase PTEN. REMD given before training is without effect, suggesting the lack of effect on the acquisition of memory. Intra-amygdala administration of antisense but not sense or scrambled oligonucleotides for PTEN prevents REMD-induced decrease in protein phosphorylation and impairment of fear memory. Thus, REMD interferes with the process of memory retention via the activation of PTEN.
AB - Although the underlying mechanism is not elucidated, it has been postulated repeatedly that deprivation of sleep, particularly rapid eye movement (REM) sleep, affects learning. Here we report that memory for newly acquired information is impaired after a specific period of REM sleep deprivation (REMD). Memory retrieval-induced phosphorylation of protein kinases in the rat amygdala is abrogated by REMD that is associated with an increase in the expression of a dual protein/lipid phosphatase PTEN. REMD given before training is without effect, suggesting the lack of effect on the acquisition of memory. Intra-amygdala administration of antisense but not sense or scrambled oligonucleotides for PTEN prevents REMD-induced decrease in protein phosphorylation and impairment of fear memory. Thus, REMD interferes with the process of memory retention via the activation of PTEN.
UR - http://www.scopus.com/inward/record.url?scp=6944219943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6944219943&partnerID=8YFLogxK
U2 - 10.1124/mol.104.001156
DO - 10.1124/mol.104.001156
M3 - Article
C2 - 15317872
AN - SCOPUS:6944219943
VL - 66
SP - 1340
EP - 1348
JO - Molecular Pharmacology
JF - Molecular Pharmacology
SN - 0026-895X
IS - 5
ER -