The management of pregnancy and pregnancy-related medical conditions in pulmonary arterial hypertension patients

Chih Hsin Hsu, M. Gomberg-Maitland, C. Glassner, J. H. Chen

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Summary Pulmonary arterial hypertension (PAH) is a complex disorder in which pulmonary arterial obstruction leads to elevated pulmonary arterial resistance and right ventricular failure. Normal physiologic changes that occur during pregnancy and immediately postpartum may produce fatal consequence in PAH patients. Pregnancy in patients with PAH has a high maternal mortality, estimated at 30-56%. Contemporary estimates of mortality are better but still prohibitively high. Current guidelines recommend that pregnancy be avoided or terminated early in women with PAH. Some patients, despite counselling by their physician, choose to continue with their pregnancy. In addition, some women first present with PAH during pregnancy leading to complex management issues in a high-risk patient. PAH-specific therapies may allow patients to better tolerate pregnancy. These patients should be treated by experienced physicians at tertiary care centres. This review article will focus on the management of the pregnant PAH patient and the preventative options available for this high-risk cohort.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalInternational Journal of Clinical Practice
Volume65
Issue numberSUPPL. 172
DOIs
Publication statusPublished - 2011 Aug

All Science Journal Classification (ASJC) codes

  • General Medicine

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