The mechanical properties of the rabbit carpal tunnel subsynovial connective tissue

Taihei Yamaguchi; Naoki Osamura; Chunfeng Zhao; Mark E. Zobitz; Kai Nan An; Peter C. Amadio

doi:10.1016/j.jbiomech.2007.06.004

The mechanical properties of the rabbit carpal tunnel subsynovial connective tissue

Taihei Yamaguchi, Naoki Osamura, Chunfeng Zhao, Mark E. Zobitz, Kai Nan An, Peter C. Amadio

Medical Device Innovation Center

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The rabbit model is commonly used to study carpal tunnel syndrome (CTS). It has been proposed that the subsynovial connective tissue (SSCT) in the carpal tunnel may play a role in the etiology of CTS, but the material properties of the rabbit SSCT are unknown. The purpose of this study was to develop a method to measure the shear properties of the rabbit SSCT. In six rabbit cadaver forepaws, the excursion of the third digit flexor digitorum superficialis (FDS) and load to failure of the SSCT were measured in a custom device. The mean excursion to full flexion in this model was 7.08 mm (S.D. 0.77). The mean shearing force at full flexion was 317 mN (S.D. 166). At full flexion percentage of maximum shear force in the SSCT was 54.5% (S.D. 19.4). The mean energy absorbed at full flexion was 0.29 mJ (S.D. 0.31). The mean excursion needed to reach 5% of the maximum shear force was 3.04 mm (S.D. 0.99). The testing model presented in this study demonstrates structural parameters to evaluate the shear properties of the SSCT in a rabbit model. The data presented could be used for estimating sample sizes in a more comprehensive study of the effect of CTS on the SSCT properties.

Original language	English
Pages (from-to)	3519-3522
Number of pages	4
Journal	Journal of Biomechanics
Volume	41
Issue number	16
DOIs	https://doi.org/10.1016/j.jbiomech.2007.06.004
Publication status	Published - 2008 Dec 5

All Science Journal Classification (ASJC) codes

Biophysics
Orthopedics and Sports Medicine
Biomedical Engineering
Rehabilitation

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10.1016/j.jbiomech.2007.06.004

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title = "The mechanical properties of the rabbit carpal tunnel subsynovial connective tissue",

abstract = "The rabbit model is commonly used to study carpal tunnel syndrome (CTS). It has been proposed that the subsynovial connective tissue (SSCT) in the carpal tunnel may play a role in the etiology of CTS, but the material properties of the rabbit SSCT are unknown. The purpose of this study was to develop a method to measure the shear properties of the rabbit SSCT. In six rabbit cadaver forepaws, the excursion of the third digit flexor digitorum superficialis (FDS) and load to failure of the SSCT were measured in a custom device. The mean excursion to full flexion in this model was 7.08 mm (S.D. 0.77). The mean shearing force at full flexion was 317 mN (S.D. 166). At full flexion percentage of maximum shear force in the SSCT was 54.5% (S.D. 19.4). The mean energy absorbed at full flexion was 0.29 mJ (S.D. 0.31). The mean excursion needed to reach 5% of the maximum shear force was 3.04 mm (S.D. 0.99). The testing model presented in this study demonstrates structural parameters to evaluate the shear properties of the SSCT in a rabbit model. The data presented could be used for estimating sample sizes in a more comprehensive study of the effect of CTS on the SSCT properties.",

author = "Taihei Yamaguchi and Naoki Osamura and Chunfeng Zhao and Zobitz, {Mark E.} and An, {Kai Nan} and Amadio, {Peter C.}",

note = "Funding Information: Funding for this study was provided by the NIH (NIAMS AR49823) and the Mayo Foundation. The study funding sponsors were not involved in the study design, collection, analysis or interpretation of the data, nor were they included in the decision to submit this work for publication.",

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AU - Osamura, Naoki

AU - Zhao, Chunfeng

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AU - An, Kai Nan

AU - Amadio, Peter C.

N1 - Funding Information: Funding for this study was provided by the NIH (NIAMS AR49823) and the Mayo Foundation. The study funding sponsors were not involved in the study design, collection, analysis or interpretation of the data, nor were they included in the decision to submit this work for publication.

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N2 - The rabbit model is commonly used to study carpal tunnel syndrome (CTS). It has been proposed that the subsynovial connective tissue (SSCT) in the carpal tunnel may play a role in the etiology of CTS, but the material properties of the rabbit SSCT are unknown. The purpose of this study was to develop a method to measure the shear properties of the rabbit SSCT. In six rabbit cadaver forepaws, the excursion of the third digit flexor digitorum superficialis (FDS) and load to failure of the SSCT were measured in a custom device. The mean excursion to full flexion in this model was 7.08 mm (S.D. 0.77). The mean shearing force at full flexion was 317 mN (S.D. 166). At full flexion percentage of maximum shear force in the SSCT was 54.5% (S.D. 19.4). The mean energy absorbed at full flexion was 0.29 mJ (S.D. 0.31). The mean excursion needed to reach 5% of the maximum shear force was 3.04 mm (S.D. 0.99). The testing model presented in this study demonstrates structural parameters to evaluate the shear properties of the SSCT in a rabbit model. The data presented could be used for estimating sample sizes in a more comprehensive study of the effect of CTS on the SSCT properties.

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The mechanical properties of the rabbit carpal tunnel subsynovial connective tissue

Abstract

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