TY - GEN
T1 - The migration of cancer and normal cells in response to the surface topography and rigidity
AU - Chen, Wen Chi
AU - Hsieh, Chin Ho
AU - Li, Chia Hui
AU - Tseng, Yu Chieh
AU - Wang, Kuo Ming
AU - Yeh, Ming Long
PY - 2011
Y1 - 2011
N2 - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.
AB - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.
UR - http://www.scopus.com/inward/record.url?scp=80053301435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053301435&partnerID=8YFLogxK
U2 - 10.1109/NEMS.2011.6017398
DO - 10.1109/NEMS.2011.6017398
M3 - Conference contribution
AN - SCOPUS:80053301435
SN - 9781612847757
T3 - NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
SP - 483
EP - 486
BT - NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
T2 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
Y2 - 20 February 2011 through 23 February 2011
ER -
