The migration of cancer and normal cells in response to the surface topography and rigidity

Wen Chi Chen; Chin Ho Hsieh; Chia Hui Li; Yu Chieh Tseng; Kuo Ming Wang; Ming Long Yeh

doi:10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity

Wen Chi Chen
, Chin Ho Hsieh
, Chia Hui Li
, Yu Chieh Tseng
, Kuo Ming Wang
, Ming Long Yeh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

Original language	English
Title of host publication	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Pages	483-486
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2011.6017398
Publication status	Published - 2011
Event	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 - Kaohsiung, Taiwan Duration: 2011 Feb 20 → 2011 Feb 23

Publication series

Name	NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Other

Other	6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011
Country/Territory	Taiwan
City	Kaohsiung
Period	11-02-20 → 11-02-23

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics

Access to Document

10.1109/NEMS.2011.6017398

Cite this

Chen, W. C., Hsieh, C. H., Li, C. H., Tseng, Y. C., Wang, K. M., & Yeh, M. L. (2011). The migration of cancer and normal cells in response to the surface topography and rigidity. In NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (pp. 483-486). Article 6017398 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). https://doi.org/10.1109/NEMS.2011.6017398

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title = "The migration of cancer and normal cells in response to the surface topography and rigidity",

abstract = "Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.",

author = "Chen, \{Wen Chi\} and Hsieh, \{Chin Ho\} and Li, \{Chia Hui\} and Tseng, \{Yu Chieh\} and Wang, \{Kuo Ming\} and Yeh, \{Ming Long\}",

year = "2011",

doi = "10.1109/NEMS.2011.6017398",

language = "English",

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series = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

pages = "483--486",

booktitle = "NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems",

note = "6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011 ; Conference date: 20-02-2011 Through 23-02-2011",

}

Chen, WC, Hsieh, CH, Li, CH, Tseng, YC, Wang, KM & Yeh, ML 2011, The migration of cancer and normal cells in response to the surface topography and rigidity. in NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems., 6017398, NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, pp. 483-486, 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2011, Kaohsiung, Taiwan, 11-02-20. https://doi.org/10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity. / Chen, Wen Chi; Hsieh, Chin Ho; Li, Chia Hui et al.
NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 483-486 6017398 (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - The migration of cancer and normal cells in response to the surface topography and rigidity

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AU - Hsieh, Chin Ho

AU - Li, Chia Hui

AU - Tseng, Yu Chieh

AU - Wang, Kuo Ming

AU - Yeh, Ming Long

PY - 2011

Y1 - 2011

N2 - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

AB - Human melanoma cells (A2058) and human epidermalmelanocytes (HEMn) were used for this study. The soft substrata were fabricated by standard concentration (101) of polydimethylsiloxane. The surface patterns included cones and grooves with line width at 1 μm and 6 μm. Directional migration, parallel migration to the groove, was observed on groove surface, no clear preferred migration orientation on the cones and flat substrata. The frequency of cells moving along the groove decreased with smaller line width. Flat-top cone was the best surface morphology to influence the spreading area of melanoma cell. The migration speed on glass was the lowest. The highest speeds of A2058 and HEMn cells were 0.69 ± 0.06 and 1.01 ± 0.29 μm/min was obtained on the 6 μm cones and 1 μm grooves respectively.

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SP - 483

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BT - NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems

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Chen WC, Hsieh CH, Li CH, Tseng YC, Wang KM, Yeh ML. The migration of cancer and normal cells in response to the surface topography and rigidity. In NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. 2011. p. 483-486. 6017398. (NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems). doi: 10.1109/NEMS.2011.6017398

The migration of cancer and normal cells in response to the surface topography and rigidity

Abstract

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UN SDGs

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