Abstract
Oral cancer is one of the most common types of human cancer in the world. Although the risk factors for oral cancer are well-recognized in different countries, the molecular mechanism responsible for this malignancy remains elusive particularly in the countries where betel quid chewing is prevalent. The cDNA microarray analysis was used to analyse the mRNA expression patterns of 1177 genes in ten oral cancer patients with betel quid chewing history. Eighty-four genes involving cell adhesion, cell shape, growth, apoptosis, angiogenesis, metastasis, and metabolism were deregulated. Although the expression profile of these genes was shared by certain clinical patients, there was no significant association of the expression profile with clinical staging. Functional implication of four validated genes including caspase-1, STAT-1, COX-2 and pleiotrophin was discussed. This study provides pilot data for understanding the pathogenesis of oral cancer in countries like Taiwan where betel quid chewing is prevalent.
| Original language | English |
|---|---|
| Pages (from-to) | 418-426 |
| Number of pages | 9 |
| Journal | Oral Oncology |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2004 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Oral Surgery
- Oncology
- Cancer Research
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The mRNA profile of genes in betel quid chewing oral cancer patients. / Tsai, Wan Chi; Tsai, Sen-Tien; Ko, Jenq Yuh; Jin, Ying Tai; Li, Ching; Huang, Wen-Ya; Young, Kung-Chia; Lai, Ming-Derg; Liu, Hsiao-Sheng; Wu, Li-Wha.
In: Oral Oncology, Vol. 40, No. 4, 01.01.2004, p. 418-426.Research output: Contribution to journal › Article
TY - JOUR
T1 - The mRNA profile of genes in betel quid chewing oral cancer patients
AU - Tsai, Wan Chi
AU - Tsai, Sen-Tien
AU - Ko, Jenq Yuh
AU - Jin, Ying Tai
AU - Li, Ching
AU - Huang, Wen-Ya
AU - Young, Kung-Chia
AU - Lai, Ming-Derg
AU - Liu, Hsiao-Sheng
AU - Wu, Li-Wha
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Oral cancer is one of the most common types of human cancer in the world. Although the risk factors for oral cancer are well-recognized in different countries, the molecular mechanism responsible for this malignancy remains elusive particularly in the countries where betel quid chewing is prevalent. The cDNA microarray analysis was used to analyse the mRNA expression patterns of 1177 genes in ten oral cancer patients with betel quid chewing history. Eighty-four genes involving cell adhesion, cell shape, growth, apoptosis, angiogenesis, metastasis, and metabolism were deregulated. Although the expression profile of these genes was shared by certain clinical patients, there was no significant association of the expression profile with clinical staging. Functional implication of four validated genes including caspase-1, STAT-1, COX-2 and pleiotrophin was discussed. This study provides pilot data for understanding the pathogenesis of oral cancer in countries like Taiwan where betel quid chewing is prevalent.
AB - Oral cancer is one of the most common types of human cancer in the world. Although the risk factors for oral cancer are well-recognized in different countries, the molecular mechanism responsible for this malignancy remains elusive particularly in the countries where betel quid chewing is prevalent. The cDNA microarray analysis was used to analyse the mRNA expression patterns of 1177 genes in ten oral cancer patients with betel quid chewing history. Eighty-four genes involving cell adhesion, cell shape, growth, apoptosis, angiogenesis, metastasis, and metabolism were deregulated. Although the expression profile of these genes was shared by certain clinical patients, there was no significant association of the expression profile with clinical staging. Functional implication of four validated genes including caspase-1, STAT-1, COX-2 and pleiotrophin was discussed. This study provides pilot data for understanding the pathogenesis of oral cancer in countries like Taiwan where betel quid chewing is prevalent.
UR - http://www.scopus.com/inward/record.url?scp=10744233965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744233965&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2003.09.015
DO - 10.1016/j.oraloncology.2003.09.015
M3 - Article
C2 - 14969821
AN - SCOPUS:10744233965
VL - 40
SP - 418
EP - 426
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 4
ER -