Multimedia instruction is an effective way to help learners create meaningful knowledge and to make referential connections between mental representations. This study aims to provide a system for manufacturing high-quality digital courses in a more easy and convenient way, namely Signature Design system (SDS). Using the proposed SDS, the teacher can layout the components of a teaching screen with a variety type of media files, such as slide and video files and the built layout can be saved and reused for other courses. Meanwhile, with a media server, a recording course can be broadcasted through the internet intermediately to provide the option for synchronous learning. There are five main advantages of the proposed SDS. First, the courses recorded through the SDS do not need enormous post-processing. In addition, the recording course can be broadcasted on the internet intermediately. Second, a variety of media such as slide, word processor and video files can be integrated into a screen. Third, to capture the teacher's front face in a better view, the SDS allows more than two DVs and the DVs can be swapped smoothly by the hot swapping control function built in SDS. Fourth, the teacher can layout the desired screen of a course and, more importantly, the designed layout is reusable for next or another course. Fifth, the teacher can quickly change the different scenes and do not have to break recording. It can provide a variety of teaching scenes to allow students to learn like in real situation.