The non-canonical role of vascular endothelial growth factor-C axis in cancer progression

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.

Original languageEnglish
Pages (from-to)718-724
Number of pages7
JournalExperimental Biology and Medicine
Volume240
Issue number6
DOIs
Publication statusPublished - 2015 Jun 12

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Vascular Endothelial Growth Factor C
Neoplasms
Tumors
Lymph Nodes
Cells
Lymphangiogenesis
Neoplasm Metastasis
Oncology
Immune system
Immune System

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "The non-canonical role of vascular endothelial growth factor-C axis in cancer progression",
abstract = "It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.",
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The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. / Wang, Chu An; Tsai, Shaw Jenq.

In: Experimental Biology and Medicine, Vol. 240, No. 6, 12.06.2015, p. 718-724.

Research output: Contribution to journalArticle

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