The non-canonical role of vascular endothelial growth factor-C axis in cancer progression

Chu An Wang, Shaw Jenq Tsai

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.

Original languageEnglish
Pages (from-to)718-724
Number of pages7
JournalExperimental Biology and Medicine
Issue number6
Publication statusPublished - 2015 Jun 12

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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