The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited pro-inflammatory cytokines

Dur Zong Hsu, Pei Yi Chu, Ming-Yi Liu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

After binding to lipopolysaccharide (LPS)-binding protein, LPS is transferred to CD14 and then to the MD2-Toll-like receptor 4 complex, which results in the progression of sepsis. We investigated how 3,4- methylenedioxyphenol (sesamol), an inexpensive natural product in sesame seeds, affects the binding of LPS and LPS-binding protein and the release of pro-inflammatory cytokines. Sesamol: (i) dose-dependently inhibited LPS from binding to LPS binding protein; (ii) significantly decreased the release of tumor necrosis factor-a and interleukin-Iß in LPS-challenged peritoneal macrophages in medium and in the serum of LPS-challenged rats; and (iii) significantly reduced the mortality rate in mice given a lethal dose of LPS. We hypothesize that sesamol blocks LPS from binding to LPSbinding protein and inhibits the release of pro-inflammatory cytokines, both of which are associated with a decrease of mortality in endotoxemia.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalInnate Immunity
Volume15
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Lipopolysaccharides
Cytokines
Sesamum
Toll-Like Receptor 4
Endotoxemia
Mortality
Peritoneal Macrophages
lipopolysaccharide-binding protein
sesamol
Biological Products
Interleukin-1
Seeds
Sepsis
Tumor Necrosis Factor-alpha
Serum
Proteins

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Molecular Biology
  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

@article{44fe348c35884cc1a3b9e26c5d3c0c96,
title = "The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited pro-inflammatory cytokines",
abstract = "After binding to lipopolysaccharide (LPS)-binding protein, LPS is transferred to CD14 and then to the MD2-Toll-like receptor 4 complex, which results in the progression of sepsis. We investigated how 3,4- methylenedioxyphenol (sesamol), an inexpensive natural product in sesame seeds, affects the binding of LPS and LPS-binding protein and the release of pro-inflammatory cytokines. Sesamol: (i) dose-dependently inhibited LPS from binding to LPS binding protein; (ii) significantly decreased the release of tumor necrosis factor-a and interleukin-I{\ss} in LPS-challenged peritoneal macrophages in medium and in the serum of LPS-challenged rats; and (iii) significantly reduced the mortality rate in mice given a lethal dose of LPS. We hypothesize that sesamol blocks LPS from binding to LPSbinding protein and inhibits the release of pro-inflammatory cytokines, both of which are associated with a decrease of mortality in endotoxemia.",
author = "Hsu, {Dur Zong} and Chu, {Pei Yi} and Ming-Yi Liu",
year = "2009",
month = "12",
day = "1",
doi = "10.1177/1753425909341806",
language = "English",
volume = "15",
pages = "380--385",
journal = "Innate Immunity",
issn = "1753-4259",
publisher = "SAGE Publications Ltd",
number = "6",

}

The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited pro-inflammatory cytokines. / Hsu, Dur Zong; Chu, Pei Yi; Liu, Ming-Yi.

In: Innate Immunity, Vol. 15, No. 6, 01.12.2009, p. 380-385.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited pro-inflammatory cytokines

AU - Hsu, Dur Zong

AU - Chu, Pei Yi

AU - Liu, Ming-Yi

PY - 2009/12/1

Y1 - 2009/12/1

N2 - After binding to lipopolysaccharide (LPS)-binding protein, LPS is transferred to CD14 and then to the MD2-Toll-like receptor 4 complex, which results in the progression of sepsis. We investigated how 3,4- methylenedioxyphenol (sesamol), an inexpensive natural product in sesame seeds, affects the binding of LPS and LPS-binding protein and the release of pro-inflammatory cytokines. Sesamol: (i) dose-dependently inhibited LPS from binding to LPS binding protein; (ii) significantly decreased the release of tumor necrosis factor-a and interleukin-Iß in LPS-challenged peritoneal macrophages in medium and in the serum of LPS-challenged rats; and (iii) significantly reduced the mortality rate in mice given a lethal dose of LPS. We hypothesize that sesamol blocks LPS from binding to LPSbinding protein and inhibits the release of pro-inflammatory cytokines, both of which are associated with a decrease of mortality in endotoxemia.

AB - After binding to lipopolysaccharide (LPS)-binding protein, LPS is transferred to CD14 and then to the MD2-Toll-like receptor 4 complex, which results in the progression of sepsis. We investigated how 3,4- methylenedioxyphenol (sesamol), an inexpensive natural product in sesame seeds, affects the binding of LPS and LPS-binding protein and the release of pro-inflammatory cytokines. Sesamol: (i) dose-dependently inhibited LPS from binding to LPS binding protein; (ii) significantly decreased the release of tumor necrosis factor-a and interleukin-Iß in LPS-challenged peritoneal macrophages in medium and in the serum of LPS-challenged rats; and (iii) significantly reduced the mortality rate in mice given a lethal dose of LPS. We hypothesize that sesamol blocks LPS from binding to LPSbinding protein and inhibits the release of pro-inflammatory cytokines, both of which are associated with a decrease of mortality in endotoxemia.

UR - http://www.scopus.com/inward/record.url?scp=74549190015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74549190015&partnerID=8YFLogxK

U2 - 10.1177/1753425909341806

DO - 10.1177/1753425909341806

M3 - Article

VL - 15

SP - 380

EP - 385

JO - Innate Immunity

JF - Innate Immunity

SN - 1753-4259

IS - 6

ER -