The Pathobiome in Animal and Plant Diseases

David Bass, Grant D. Stentiford, Han Ching Wang, Britt Koskella, Charles R. Tyler

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

A growing awareness of the diversity and ubiquity of microbes (eukaryotes, prokaryotes, and viruses) associated with larger ‘host’ organisms has led to the realisation that many diseases thought to be caused by one primary agent are the result of interactions between multiple taxa and the host. Even where a primary agent can be identified, its effect is often moderated by other symbionts. Therefore, the one pathogen–one disease paradigm is shifting towards the pathobiome concept, integrating the interaction of multiple symbionts, host, and environment in a new understanding of disease aetiology. Taxonomically, pathobiomes are variable across host species, ecology, tissue type, and time. Therefore, a more functionally driven understanding of pathobiotic systems is necessary, based on gene expression, metabolic interactions, and ecological processes.

Original languageEnglish
Pages (from-to)996-1008
Number of pages13
JournalTrends in Ecology and Evolution
Volume34
Issue number11
DOIs
Publication statusPublished - 2019 Nov

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics

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    Bass, D., Stentiford, G. D., Wang, H. C., Koskella, B., & Tyler, C. R. (2019). The Pathobiome in Animal and Plant Diseases. Trends in Ecology and Evolution, 34(11), 996-1008. https://doi.org/10.1016/j.tree.2019.07.012