The photothermal effect of silica-carbon hollow sphere-concanavalin A on liver cancer cells

Ying Chi Chen, Wen-Tai Chiu, Jung Chih Chen, Chia Sheng Chang, Lily Hui-Ching Wang, Hong-Ping Lin, Hsien-Chang Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers and causes of death by cancer. Concanavalin A (ConA) lectin can specifically bind to the glycoprotein receptors of HCC, which are produced by the aberrant overexpression of liver cancer cells. ConA was used in the current study to conjugate on silica-carbon hollow spheres (SCHSs) and applied in the thermal ablation therapy of liver cancer cell lines under near-infrared (NIR) laser irradiation. We found that the amount of ConA-SCHS complex binding to hepatoma cells was significantly higher than that seen with normal hepatocytes, based on flow cytometric analysis and confocal imaging. Hepatoma cells incubated with ConA-SCHSs were thus more easily killed by the subsequent irradiation with a NIR laser. The results show that the ConA-SCHS complex may enhance the interaction with highly expressed ConA receptors on hepatoma cells, and thus serve as an effective photothermal therapy agent for liver cancer treatment.

Original languageEnglish
Pages (from-to)2447-2454
Number of pages8
JournalJournal of Materials Chemistry B
Volume3
Issue number12
DOIs
Publication statusPublished - 2015 Mar 28

Fingerprint

Liver Neoplasms
Concanavalin A
Silicon Dioxide
Liver
Hepatocellular Carcinoma
Carbon
Silica
Cells
Infrared lasers
Lasers
Glycoproteins
Concanavalin A Receptors
Oncology
Laser beam effects
Ablation
Lectins
Irradiation
Cause of Death
Hepatocytes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Chen, Ying Chi ; Chiu, Wen-Tai ; Chen, Jung Chih ; Chang, Chia Sheng ; Hui-Ching Wang, Lily ; Lin, Hong-Ping ; Chang, Hsien-Chang. / The photothermal effect of silica-carbon hollow sphere-concanavalin A on liver cancer cells. In: Journal of Materials Chemistry B. 2015 ; Vol. 3, No. 12. pp. 2447-2454.
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The photothermal effect of silica-carbon hollow sphere-concanavalin A on liver cancer cells. / Chen, Ying Chi; Chiu, Wen-Tai; Chen, Jung Chih; Chang, Chia Sheng; Hui-Ching Wang, Lily; Lin, Hong-Ping; Chang, Hsien-Chang.

In: Journal of Materials Chemistry B, Vol. 3, No. 12, 28.03.2015, p. 2447-2454.

Research output: Contribution to journalArticle

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AU - Chiu, Wen-Tai

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AU - Chang, Chia Sheng

AU - Hui-Ching Wang, Lily

AU - Lin, Hong-Ping

AU - Chang, Hsien-Chang

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AB - Hepatocellular carcinoma (HCC) is one of the most common cancers and causes of death by cancer. Concanavalin A (ConA) lectin can specifically bind to the glycoprotein receptors of HCC, which are produced by the aberrant overexpression of liver cancer cells. ConA was used in the current study to conjugate on silica-carbon hollow spheres (SCHSs) and applied in the thermal ablation therapy of liver cancer cell lines under near-infrared (NIR) laser irradiation. We found that the amount of ConA-SCHS complex binding to hepatoma cells was significantly higher than that seen with normal hepatocytes, based on flow cytometric analysis and confocal imaging. Hepatoma cells incubated with ConA-SCHSs were thus more easily killed by the subsequent irradiation with a NIR laser. The results show that the ConA-SCHS complex may enhance the interaction with highly expressed ConA receptors on hepatoma cells, and thus serve as an effective photothermal therapy agent for liver cancer treatment.

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