The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population

J. Y. Wang, S. D. Shyur, W. H. Wang, Y. H. Liou, C. G.J. Lin, Y. J. Wu, L. S.H. Wu

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL17A and asthma in Taiwanese children. Methods: We selected and performed genotyping on nine SNPs that encompass the genomic region of IL17A in Taiwanese children with or without asthma. A total of 1939 subjects containing 1027 subjects in testing group and 931 subjects in validation group were recruited in this study. Results: After Bonferroni correction, SNP rs8193036 was found to have a weak association (P = 0.0074 × 9 = 0.066) in genotype frequency test. This association was confirmed by validation group. Logistic regression adjusted allergy comorbidity and gender showed a slightly weaker association. Conclusions: The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.

Original languageEnglish
Pages (from-to)1056-1060
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume64
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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