The predictive value of global longitudinal strain in patients with heart failure mid-range ejection fraction

Wei Ting Chang, Chih Hsien Lin, Chon Seng Hong, Chia Te Liao, Yen Wen Liu, Zhih Cherng Chen, Jhih Yuan Shih

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Heart failure (HF) with mid-range ejection fraction (HFmrEF) is defined as HF with a left ventricular (LV) ejection fraction (LVEF) of 41–49%. However, the change in LV function and the subsequent prognosis in these patients remain unclear. We aimed to investigate whether LV global longitudinal strain (LV GLS) could differentiate the changes in LVEF and predict the clinical outcomes in patients with HFmrEF. Methods: According to the changes in LVEF on follow-up echocardiography, 273 outpatients with HFmrEF were divided into 3 groups: HFwEF (HF with worse EF: <40%), HFsEF (HF with similar EF: 40–49%), and HFrecEF (HF with recovered EF: >50%). Further, the LV GLS at diagnosis was evaluated. Results: The average follow-up duration was 31 months. Among patients with HFmrEF, the more impaired the LV GLS at baseline, the higher probability of HFwEF development. In comparison with patients with HFwEF and HFsEF, those with HFrecEF had a lower risk of hospitalization for HF. At a cut-off value of −11%, LV GLS differentiated the subsequent risk of cardiovascular death in patients with HFmrEF. In Cox regression, patients with LV GLS >−11% had a high risk of cardiovascular death. Conclusion: In patients with HFmrEF, LV GLS is associated with LVEF changes and subsequent cardiovascular death. Patients with HFrecEF had a lower risk of hospitalization for HF.

Original languageEnglish
Pages (from-to)509-516
Number of pages8
JournalJournal of Cardiology
Volume77
Issue number5
DOIs
Publication statusPublished - 2021 May

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'The predictive value of global longitudinal strain in patients with heart failure mid-range ejection fraction'. Together they form a unique fingerprint.

Cite this