The prevalence of erythromycin resistance in group B streptococcal isolates at a university hospital in Taiwan

Rajendra Prasad Janapatla, Yueh-Ren Ho, Jing Jou Yan, Hsiu Mei Wu, Jiunn Jong Wu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Due to reduced antibiotic consumption in Taiwan, erythromycin resistance rate had decreased in Streptococcus pyogenes, but it increased in Streptococcus pneumoniae. The objectives of the present study were (1) to determine the erythromycin and clindamycin resistance rate and minimum inhibitory concentration (MIC) of the group B streptococcus (GBS) clinical isolates, and (2) to investigate the mechanism responsible for the macrolide, lincosamide, and group B streptogramin (MLSB) resistance. A total of 1,395 GBS isolates were collected from June 2001 to April 2007. Forty-four percent of the GBS isolates were resistant to erythromycin, and 39% were resistant to clindamycin. The annual erythromycin resistance rate increased from 32% in 2001 to 51% in 2004; a significant decrease was observed in 2005 (47%), 2006 (42%), and 2007 (38%). Percentage of erythromycin-resistant isolates with erm(B) gene significantly increased from 72% in 2001 to 90% in 2007. We found that the plasmid encoded zeta gene was present in 13% of the resistant isolates, along with erm(B). When compared to our previous study (1991 to May 2001), the overall erythromycin resistance rate increased from 30% to 44%. erm(B) was the major resistant determinant, and zeta toxin encoding plasmid has a limited role in mediating erythromycin resistance unlike in GAS isolates as reported earlier.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalMicrobial Drug Resistance
Volume14
Issue number4
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Erythromycin
Taiwan
Streptococcus agalactiae
Clindamycin
Streptogramin Group B
Plasmids
Lincosamides
Streptococcus pyogenes
Macrolides
Microbial Sensitivity Tests
Streptococcus pneumoniae
Genes
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

Cite this

Janapatla, Rajendra Prasad ; Ho, Yueh-Ren ; Yan, Jing Jou ; Wu, Hsiu Mei ; Wu, Jiunn Jong. / The prevalence of erythromycin resistance in group B streptococcal isolates at a university hospital in Taiwan. In: Microbial Drug Resistance. 2008 ; Vol. 14, No. 4. pp. 293-297.
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abstract = "Due to reduced antibiotic consumption in Taiwan, erythromycin resistance rate had decreased in Streptococcus pyogenes, but it increased in Streptococcus pneumoniae. The objectives of the present study were (1) to determine the erythromycin and clindamycin resistance rate and minimum inhibitory concentration (MIC) of the group B streptococcus (GBS) clinical isolates, and (2) to investigate the mechanism responsible for the macrolide, lincosamide, and group B streptogramin (MLSB) resistance. A total of 1,395 GBS isolates were collected from June 2001 to April 2007. Forty-four percent of the GBS isolates were resistant to erythromycin, and 39{\%} were resistant to clindamycin. The annual erythromycin resistance rate increased from 32{\%} in 2001 to 51{\%} in 2004; a significant decrease was observed in 2005 (47{\%}), 2006 (42{\%}), and 2007 (38{\%}). Percentage of erythromycin-resistant isolates with erm(B) gene significantly increased from 72{\%} in 2001 to 90{\%} in 2007. We found that the plasmid encoded zeta gene was present in 13{\%} of the resistant isolates, along with erm(B). When compared to our previous study (1991 to May 2001), the overall erythromycin resistance rate increased from 30{\%} to 44{\%}. erm(B) was the major resistant determinant, and zeta toxin encoding plasmid has a limited role in mediating erythromycin resistance unlike in GAS isolates as reported earlier.",
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The prevalence of erythromycin resistance in group B streptococcal isolates at a university hospital in Taiwan. / Janapatla, Rajendra Prasad; Ho, Yueh-Ren; Yan, Jing Jou; Wu, Hsiu Mei; Wu, Jiunn Jong.

In: Microbial Drug Resistance, Vol. 14, No. 4, 01.12.2008, p. 293-297.

Research output: Contribution to journalArticle

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