TY - JOUR
T1 - The profile and familiality of personality traits in mood disorder families
AU - Wu, Pei Jung
AU - Chang, Sheng Mao
AU - Lu, Ming Kun
AU - Chen, Wei J.
AU - Yang, Yen Kuang
AU - Tzung-Liehyeh,
AU - Liao, Shin Cheng
AU - Lu, Ru Band
AU - Kuo, Po Hsiu
N1 - Funding Information:
Funding for this study was supported by the National Science Council grants: NSC 97-2314-B-002-184-MY2, NSC 99-2314-B-002-140-MY3 and by the National Health Research Institute grant: EX99-9918NC to Kuo, P.H. The funding sources had no further role in the study design, collection, analysis, or interpretation of data, in writing of the report, and in the decision to submit the paper for publication.
PY - 2012/5
Y1 - 2012/5
N2 - Objective: Personality traits have impacts on individuals' response to stress and mood expression. The current study aimed to investigate the profile of personality traits in patients with bipolar disorders and major depressive disorder (MDD). Familial aggregation of personality traits in mood disorder families was also evaluated. Methods: We recruited 260 clinical patients of MDD (92), bipolar disorder-I and II (BP-I = 111, BP-II = 57), 190 first-degree relatives, and 180 controls. Four personality traits were assessed using the Eysenck and Tridimensional Personality Questionnaires, including Extraversion (E), Neuroticism (N), Harm Avoidance (HA), and Novelty Seeking (NS). The magnitude of familiality of personality traits in mood disorder families was evaluated by mixed models and intra-class correlation coefficients (ICC). Results: Patients with mood disorders had lower E, and higher N, HA and NS than controls. Unaffected relatives were not differed from controls in the four personality traits. BP-I had higher E, NS and lower N, HA than MDD patients (p < 0.01). The scale N further distinguished BP-I from BP-II (p = 0.02) with lower N among BP-I patients. There exhibited moderate familiality in E (ICC = 0.184-0.239) and HA (ICC = 0.355) in bipolar disorder families. Limitation: Personality traits were accessed cross-sectionally without quantitatively controlled severity of mood symptoms. Conclusion: Different patterns of personality traits distinguish patients from unaffected individuals as well as separate diagnoses of mood disorders, indicating the usage of more comprehensive evaluation of personality traits in clinical settings. Familiality of extraversion and harm avoidance in bipolar disorder families provides insights for further investigating correlates of comorbid behavioral problems in bipolar disorders.
AB - Objective: Personality traits have impacts on individuals' response to stress and mood expression. The current study aimed to investigate the profile of personality traits in patients with bipolar disorders and major depressive disorder (MDD). Familial aggregation of personality traits in mood disorder families was also evaluated. Methods: We recruited 260 clinical patients of MDD (92), bipolar disorder-I and II (BP-I = 111, BP-II = 57), 190 first-degree relatives, and 180 controls. Four personality traits were assessed using the Eysenck and Tridimensional Personality Questionnaires, including Extraversion (E), Neuroticism (N), Harm Avoidance (HA), and Novelty Seeking (NS). The magnitude of familiality of personality traits in mood disorder families was evaluated by mixed models and intra-class correlation coefficients (ICC). Results: Patients with mood disorders had lower E, and higher N, HA and NS than controls. Unaffected relatives were not differed from controls in the four personality traits. BP-I had higher E, NS and lower N, HA than MDD patients (p < 0.01). The scale N further distinguished BP-I from BP-II (p = 0.02) with lower N among BP-I patients. There exhibited moderate familiality in E (ICC = 0.184-0.239) and HA (ICC = 0.355) in bipolar disorder families. Limitation: Personality traits were accessed cross-sectionally without quantitatively controlled severity of mood symptoms. Conclusion: Different patterns of personality traits distinguish patients from unaffected individuals as well as separate diagnoses of mood disorders, indicating the usage of more comprehensive evaluation of personality traits in clinical settings. Familiality of extraversion and harm avoidance in bipolar disorder families provides insights for further investigating correlates of comorbid behavioral problems in bipolar disorders.
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U2 - 10.1016/j.jad.2012.01.015
DO - 10.1016/j.jad.2012.01.015
M3 - Article
C2 - 22331025
AN - SCOPUS:84862790676
SN - 0165-0327
VL - 138
SP - 367
EP - 374
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 3
ER -